| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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|
タイトル |
ATM mediates pRBfunction to control DNMT1 protein stability and DNA methylation |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027453 |
|
ID登録タイプ |
JaLC |
| その他のタイトル |
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|
値 |
ATMを介してRBタンパク質はDNMT1タンパク質の安定性とDNAメチル化を制御する |
| 著者 |
Shamma, Awad
Suzuki, Misa
Hayashi, Naoyuki
Kobayashi, Masahiko
Sasaki, Nobunari
Nishiuchi, Takumi
Doki, Yuichiro
Okamoto, Takahiro
Kohno, Susumu
Muranaka, Hayato
Kitajima, Shunsuke
Yamamoto, Ken-ichi
Takahashi, Chiaki
|
| 著者別表示 |
林, 直之
小林, 昌彦
西内, 巧
土岐, 祐一郎
岡本, 隆寛
山本, 健一
高橋, 智聡
|
| 書誌情報 |
Molecular biology of the cell
巻 33,
号 16,
p. 3113-3124,
発行日 2013-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1059-1524 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11052919 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1128/MCB.01597-12 |
| 出版者 |
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出版者 |
American Society for Cell Biology |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The retinoblastoma tumor suppressor gene (RB) product has been implicated in epigenetic control of gene expression owing to its ability to physically bind to many chromatin modifiers. However, the biological and clinical significance of this activity was not well elucidated. To address this, we performed genetic and epigenetic analyses in an Rb-deficient mouse thyroid C cell tumor model. Here we report that the genetic interaction of Rb and ATM regulates DNMT1 protein stability and hence controls the DNA methylation status in the promoters of at least the Ink4a, Shc2, FoxO6, and Noggin genes. Furthermore, we demonstrate that inactivation of pRB promotes Tip60 (acetyltransferase)-dependent ATM activation; allows activated ATM to physically bind to DNMT1, forming a complex with Tip60 and UHRF1 (E3 ligase); and consequently accelerates DNMT1 ubiquitination driven by Tip60-dependent acetylation. Our results indicate that inactivation of the pRB pathway in coordination with aberration in the DNA damage response deregulates DNMT1 stability, leading to an abnormal DNA methylation pattern and malignant progression. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
CA-PR-SHAMMA-A-3113.pdf (5.1 MB)
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