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Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation
https://doi.org/10.24517/00027494
https://doi.org/10.24517/00027494e42f4a0e-d0fc-40ee-a297-04b3e8efee4e
| 名前 / ファイル | ライセンス | アクション |
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CA-PR-SUDA-T-24517.pdf (2.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2017-10-05 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.24517/00027494 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
Zhang, Peipei
× Zhang, Peipei× Tsuchiya, Kohsuke× Kinoshita, Takeshi× Kushiyama, Hiroko× Suidasari, Sofya× Hatakeyama, Mizuki× Imura, Hisanori× Kato, Norihisa× Suda, Takashi |
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| 著者別表示 |
土屋, 晃介
× 土屋, 晃介
× 木下, 健
× 井村, 久則
× 須田, 貴司
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| 書誌情報 |
Journal of Biological Chemistry 巻 291, 号 47, p. 24517-24527, 発行日 2016-11-18 |
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| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0021-9258 | |||||||||||||
| NCID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00251083 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1074/jbc.M116.743815 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | American Society for Biochemistry and Molecular Biology | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Vitamin B6 includes six water-soluble vitamers: pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), and their phosphorylated forms. Pyridoxal 5o'-phosphate (PLP) is an important cofactor for many metabolic enzymes. Several lines of evidence demonstrate that blood levels of PLP are significantly lower in patients with inflammation than in control subjects and that vitamin B6 has anti-inflammatory effects, with therapeutic potential for a variety of inflammatory diseases. Although one of our group previously demonstrated that PL inhibits the NF-κB pathway, the molecular mechanism by which vitamin B6 suppresses inflammation is not well understood. Here, we showed that both PL and PLP suppressed the expression of cytokine genes in macrophages by inhibiting Toll-like receptor (TLR)-mediated TAK1 phosphorylation and the subsequent NF-κB and JNK activation. Furthermore, PL and PLP abolished NLRP3-dependent caspase-1 processing and the subsequent secretion of mature IL-1β and IL-18 in LPS-primed macrophages. In contrast, PM and PN had little effect on IL-1β production. PLP, but not PL, markedly reduced the production of mitochondrial reactive oxygen species (ROS) in peritoneal macrophages. Importantly, PL and PLP reduced IL-1β production induced by LPS and ATP, or by LPS alone, in mice. Moreover, PL and PLP protected mice from lethal endotoxic shock. Collectively, these findings reveal novel anti-inflammatory activities for vitamin B6 and suggest its potential for preventing inflammatory diseases driven by the NLRP3 inflammasome. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. | |||||||||||||
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| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
