{"_buckets": {"deposit": "6e644fbb-3f2c-41ea-8a19-25d90ed9d38e"}, "_deposit": {"created_by": 3, "id": "27533", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "27533"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00027533", "sets": ["1779"]}, "author_link": ["142", "48013", "47932", "48016", "48015", "48014", "2674", "183", "3014"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-08-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "1611", "bibliographicPageStart": "1602", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "Cancer Science"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "中里, 亮太"}], "nameIdentifiers": [{"nameIdentifier": "3014", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30761803", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30761803"}]}, {"creatorNames": [{"creatorName": "鈴木, 健之"}], "nameIdentifiers": [{"nameIdentifier": "183", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30262075", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30262075"}, {"nameIdentifier": "30262075", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030262075"}]}, {"creatorNames": [{"creatorName": "善岡, 克次"}], "nameIdentifiers": [{"nameIdentifier": "2674", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60200937", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60200937"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Cutaneous melanoma is the most aggressive form of skin cancer. This aggressiveness appears to be due to the cancer cells\u0027 ability to reversibly switch between phenotypes with non-invasive and invasive potential, and microphthalmia-associated transcription factor (MITF) is known to play a central role in this process. The transcription factor glioma-associated oncogene homolog 1 (GLI1) is a component of the canonical and noncanonical sonic hedgehog pathways. Although GLI1 has been suggested to be involved in melanoma progression, its precise role and the mechanism underlying invasion remain unclear. Here we investigated whether and how GLI1 is involved in the invasive ability of melanoma cells. Gli1 knockdown (KD) melanoma cell lines, established by using Gli1-targeting lentiviral short hairpin RNA, exhibited a markedly reduced invasion ability, but their MITF expression and activity were the same as controls. Gli1 KD melanoma cells also led to less lung metastasis in mice compared with control melanoma cells. Furthermore, the Gli1 KD melanoma cells underwent a mesenchymal-to-epithelial-like transition, accompanied by downregulation of the epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (EMT-TF) Snail1, Zeb1 and Twist1, but not Snail2 or Zeb2. Collectively, these results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF, most likely by modulating a subset of EMT-TF. Our findings provide new insight into how heterogeneity and plasticity are achieved and regulated in melanoma. © 2017 Japanese Cancer Association.", "subitem_description_type": "Abstract"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00027520", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Japanese Cancer Association = 日本癌学会/ Blackwell Publishing Ltd"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/cas.13294", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://onlinelibrary.wiley.com/doi/10.1111/cas.13294", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jca.gr.jp/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2017 The Authors. Cancer Science published by John Wiley \u0026 Sons Australia, Ltd on behalf of Japanese Cancer Association. | The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1111/cas.13294 (CC-BY NC ND)"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11808050", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-9032", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Gunarta, I Ketut"}], "nameIdentifiers": [{"nameIdentifier": "48013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Rong"}], "nameIdentifiers": [{"nameIdentifier": "48014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakazato, Ryota"}], "nameIdentifiers": [{"nameIdentifier": "47932", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30761803", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30761803"}, {"nameIdentifier": "30761803", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030761803"}]}, {"creatorNames": [{"creatorName": "Suzuki, Ryusuke"}], "nameIdentifiers": [{"nameIdentifier": "48015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Boldbaatar, Jambaldorj"}], "nameIdentifiers": [{"nameIdentifier": "48016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "183", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30262075", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30262075"}, {"nameIdentifier": "30262075", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030262075"}]}, {"creatorNames": [{"creatorName": "Yoshioka, Katsuji"}], "nameIdentifiers": [{"nameIdentifier": "142", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60200937", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60200937"}, {"nameIdentifier": "60200937", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60200937"}, {"nameIdentifier": "60200937", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060200937"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-YOSHIOKA-K-1602.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "CA-PR-YOSHIOKA-K-1602.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/27533/files/CA-PR-YOSHIOKA-K-1602.pdf"}, "version_id": "77c9d6f9-873f-49e6-8121-d52e878c95d7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "GLI1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Invasion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Melanoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Metastasis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumor heterogeneity", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells"}]}, "item_type_id": "4", "owner": "3", "path": ["1779"], "permalink_uri": "https://doi.org/10.24517/00027520", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "27533", "relation": {}, "relation_version_is_last": true, "title": ["Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells"], "weko_shared_id": 3}