| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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|
タイトル |
Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027520 |
|
ID登録タイプ |
JaLC |
| 著者 |
Gunarta, I Ketut
Li, Rong
Nakazato, Ryota
Suzuki, Ryusuke
Boldbaatar, Jambaldorj
Suzuki, Takeshi
Yoshioka, Katsuji
|
| 著者別表示 |
中里, 亮太
鈴木, 健之
善岡, 克次
|
| 書誌情報 |
Cancer Science
巻 108,
号 8,
p. 1602-1611,
発行日 2017-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1347-9032 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11808050 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
|
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関連識別子 |
10.1111/cas.13294 |
| 出版者 |
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出版者 |
Japanese Cancer Association = 日本癌学会/ Blackwell Publishing Ltd |
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Cutaneous melanoma is the most aggressive form of skin cancer. This aggressiveness appears to be due to the cancer cells' ability to reversibly switch between phenotypes with non-invasive and invasive potential, and microphthalmia-associated transcription factor (MITF) is known to play a central role in this process. The transcription factor glioma-associated oncogene homolog 1 (GLI1) is a component of the canonical and noncanonical sonic hedgehog pathways. Although GLI1 has been suggested to be involved in melanoma progression, its precise role and the mechanism underlying invasion remain unclear. Here we investigated whether and how GLI1 is involved in the invasive ability of melanoma cells. Gli1 knockdown (KD) melanoma cell lines, established by using Gli1-targeting lentiviral short hairpin RNA, exhibited a markedly reduced invasion ability, but their MITF expression and activity were the same as controls. Gli1 KD melanoma cells also led to less lung metastasis in mice compared with control melanoma cells. Furthermore, the Gli1 KD melanoma cells underwent a mesenchymal-to-epithelial-like transition, accompanied by downregulation of the epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (EMT-TF) Snail1, Zeb1 and Twist1, but not Snail2 or Zeb2. Collectively, these results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF, most likely by modulating a subset of EMT-TF. Our findings provide new insight into how heterogeneity and plasticity are achieved and regulated in melanoma. © 2017 Japanese Cancer Association. |
| 権利 |
|
|
権利情報 |
Copyright © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1111/cas.13294 (CC-BY NC ND) |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://onlinelibrary.wiley.com/doi/10.1111/cas.13294 |
| 関連URI |
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|
識別子タイプ |
URI |
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関連識別子 |
http://www.jca.gr.jp/ |
CA-PR-YOSHIOKA-K-1602.pdf (1.6 MB)
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