| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
|
|
タイトル |
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027523 |
|
ID登録タイプ |
JaLC |
| 著者 |
Takino, Takahisa
Nakada, Mitsutoshi
Li, Zichen
Yoshimoto, Taisuke
Domoto, Takahiro
Sato, Hiroshi
|
| 著者別表示 |
滝野, 隆久
中田, 光俊
堂本, 貴寛
佐藤, 博
|
| 書誌情報 |
Clinical and Experimental Metastasis
巻 33,
号 1,
p. 45-52,
発行日 2016-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0262-0898 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1064065X |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s10585-015-9756-8 |
| 出版者 |
|
|
出版者 |
Springer Verlag |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A histone acetyltransferase Tat-interacting protein 60 kDa (Tip60) regulates the DNA damage response by acetylating histone and remodeling chromatin. In addition to histone acetyltransferase activity, Tip60 is known to regulate a variety of cellular functions, including gene expression, DNA damage response, cell migration and apoptosis. Lower expression of Tip60 is observed in lymphomas, melanomas, breast, colon, and lung cancer. It is widely accepted that Tip60 functions as a tumor suppressor. However, a role of Tip60 in gliomas still remains unclear. In this study, we investigated the role of Tip60 in the malignant behavior of human gliomas. By quantitative RT-PCR analysis using fresh human brain tumor tissues from 55 patients, we found that lower Tip60 expression and higher membrane-type 1 matrix metalloproteinase (MT1-MMP) expression are associated with advanced tumor grade in glioma tissues. Knockdown of Tip60 in glioblastoma cells promoted cell adhesion, spreading and MT1-MMP transcription and thereby invasion, which was suppressed by inhibition of MT1-MMP and nuclear factor-kappa B (NF-κB) activity. We demonstrate for the first time that tumor suppressor Tip60 down-regulates cell adhesion and MT1-MMP expression and thereby invasion of glioblastoma cells by suppressing NF-κB pathway. © 2015 Springer Science+Business Media Dordrecht |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
CA-PR-TAKINO-T-45.pdf (629.0 kB)
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