| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00027529 |
|
ID登録タイプ |
JaLC |
| 著者 |
Du, Yu-Chen
Oshima, Hiroko
Oguma, Keisuke
Kitamura, Takanori
Itadani, Hiraku
Fujimura, Takashi
Piao, Ying-Shi
Yoshimoto, Tanihiro
Minamoto, Toshinari
Kotani, Hidehito
Taketo, Makoto M.
Oshima, Masanobu
|
| 著者別表示 |
大島, 浩子
小熊, 圭祐
藤村, 隆
吉本, 谷博
武藤, 誠
大島, 正伸
|
| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学がん研究所がん幹細胞研究センター |
| 書誌情報 |
Gastroenterology
巻 137,
号 4,
p. 1346-1357,
発行日 2009-10-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0016-5085 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0065394X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1053/j.gastro.2009.06.041 |
| 出版者 |
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出版者 |
Elsevier |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background & Aims: The activation of Wnt/ﾎｲ-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/ﾎｲ-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. Methods: Sox17 expression was examined in gastrointestinal tumors of mouse models and humans. The roles of Sox17 in gastric tumorigenesis were examined by cell culture experiments and by construction of Sox17 transgenic mice. Results: Sox17 was induced in K19-Wnt1/C2mE mouse gastric tumors and K19-Wnt1 preneoplastic lesions, where Wnt/ﾎｲ-catenin signaling was activated. Consistently, Wnt activation induced Sox17 expression in gastric cancer cells. In contrast, Sox17 was rarely detected by immunohistochemistry in gastric and colon cancers, whereas strong nuclear staining of Sox17 was found in >70% of benign gastric and intestinal tumors. Treatment with a demethylating agent induced Sox17 expression in gastric cancer cells, thus indicating the down-regulation of Sox17 by methylation. Moreover, transfection of Sox17 in gastric cancer cells suppressed both the Wnt activity and colony formation efficiency. Finally, transgenic expression of Sox17 suppressed dysplastic tumor development in K19-Wnt1/C2mE mouse stomach. Conclusions: Sox17 plays a tumor suppressor role through suppression of Wnt signaling. However, Sox17 is induced by Wnt activation in the early stage of gastrointestinal tumorigenesis, and Sox17 is down-regulated by methylation during malignant progression. It is therefore conceivable that Sox17 protects benign tumors from malignant progression at an early stage of tumorigenesis, and down-regulation of Sox17 contributes to malignant progression through promotion of Wnt activity. © 2009 AGA Institute. |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.elsevier.com/locate/issn/00165085 |
CA-PR-OSHIMA-M-1346.pdf (3.0 MB)
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