| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
The Scaffold Protein c-Jun NH2-Terminal Kinase-associated Leucine Zipper Protein Regulates Cell Migration through Interaction with the G Protein G13 |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00027541 |
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ID登録タイプ |
JaLC |
| 著者 |
Gantulga, Davaakhuu
Tuvshintugs, Baljinnyam
Endo, Yoshio
Takino, Takahisa
Sato, Hiroshi
Murakami, Seishi
Yoshioka, Katsuji
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| 著者別表示 |
遠藤, 良夫
滝野, 隆久
佐藤, 博
村上, 清史
善岡, 克次
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学がん研究所がん分子細胞制御 |
| 書誌情報 |
Journal of Biochemistry
巻 144,
号 6,
p. 693-700,
発行日 2008-12-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021-924X |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00694073 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1093/jb/mvn123 |
| 出版者 |
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出版者 |
日本生化学会 = Japanese Biochemical Society |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Scaffold proteins for MAP kinase (MAPK) signalling modules play an important role in the specific and efficient signal transduction of the relevant MAPK cascades. Here, we investigated the function of the scaffolding protein c-Jun NH2-terminal kinase (JNK)-associated leucine zipper protein (JLP) by depleting it in cultured cells using a short hairpin RNA (shRNA) against human JLP. HeLa and DLD-1 cells stably expressing the shRNA showed a defect in cell migration. The re-expression of full-length shRNA-resistant mouse JLP rescued the impaired cell migration of the JLP-depleted HeLa cells; whereas, a C-terminal deletion mutant of mouse JLP, which failed to bind the G protein Gα13, showed little or no effect on the cell migration defect. Furthermore, although a constitutively active Gα13 enhanced the migration of control HeLa cells, the Gα13-induced cell migration was significantly suppressed in the JLP-depleted HeLa cells. Taken together, these results suggest that JLP regulates cell migration through an interaction with Gα13. © The Authors 2008. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved. |
| 権利 |
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権利情報 |
© The Authors 2008. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1093/jb/mvn123 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://jb.oxfordjournals.org/cgi/content/abstract/144/6/693 |
CA-PR-YOSHIOKA-K-693.pdf (253.1 kB)
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