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Regulation of autophagy by nucleoporin Tpr
https://doi.org/10.24517/00031236
https://doi.org/10.24517/000312362e7e013a-02da-4911-b8f0-b14fd3955759
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FR-PR-FUNASAKA-T-00878.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-10-05 | |||||||
| タイトル | ||||||||
| タイトル | Regulation of autophagy by nucleoporin Tpr | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00031236 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Funasaka, Tatsuyoshi
× Funasaka, Tatsuyoshi× Tsuka, Eriko× Wong, Richard W. |
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| 著者別表示 |
船坂, 龍善
× 船坂, 龍善
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| 書誌情報 |
Scientific Reports 巻 2, p. 878, 発行日 2012-01-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2045-2322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/srep00878 | |||||||
| 出版者 | ||||||||
| 出版者 | Nature Publishing Group | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The nuclear pore complex (NPC) consists of a conserved set of ∼30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe reduction in the number of nuclear pores. Furthermore, our electron microscopy studies indicated a significant reduction in the number of inner nuclear filaments. In addition, Tpr siRNA treatment impaired cell growth and proliferation compared to control siRNA-treated cells. In Tpr-depleted cells, the levels of p53 and p21 proteins were enhanced. Surprisingly, Tpr depletion increased p53 nuclear accumulation and facilitated autophagy. Our study demonstrates for the first time that Tpr plays a role in autophagy through controlling HSP70 and HSF1 mRNA export, p53 trafficking with karyopherin CRM1, and potentially through direct transcriptional regulation of autophagy factors. © 2012 Macmillan Publishers Limited. All rights reserved. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
