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食餌同期性概日リズムを刻む視床下部背内側核ニューロンの機能解析
https://doi.org/10.24517/00034603
https://doi.org/10.24517/00034603957cf74f-9bf4-4e8f-868b-4463c7bb5728
名前 / ファイル | ライセンス | アクション |
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ME-PR-MIEDA-M-kanen 2012-4p.pdf (239.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 食餌同期性概日リズムを刻む視床下部背内側核ニューロンの機能解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Function of food-entrainable clock neurons in the dorsomedial hypothalamic nucleus | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034603 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Mieda, Michihiro
× Mieda, Michihiro |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2011 Fiscal Year Final Research Report 巻 2008-2011, p. 4p., 発行日 2012-05-15 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 毎日固定した一定時間帯でのみ餌が得られる環境下では、動物は給餌前数時間にわたり食物探索行動を示し、給餌時間内に十分量摂食するように順応する。この食餌同期性概日行動リズムは、哺乳類の概日リズム制御中枢・視交叉上核(SCN)とは別の生物時計(食餌同期性クロック)によって制御されるが、その詳しいメカニズムは分かっていなかった。本研究で、食餌同期性クロックが機能するためには、脳内の視交叉上核以外の場所における時計遺伝子Bmal1の働きが必要であることが明らかになった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | When food availability is temporally restricted to a fixed time of the day(restricted feeding), animals adapt to this condition within a few days by feeding during the period of food availability and increasing food-seeking activity in the preceding hours. These changes in biological rhythms have been postulated to be brought about by a food-entrainable oscillator(FEO) that is independent of the mammalian master clock in the suprachiasmatic nucleus(SCN), although little is known of the physical and molecular substrates of the FEO. In this study, we demonstrated that an SCN-independent FEO in the nervous system requires a clock gene, Bmal1, and plays a critical role in adaptation of circadian locomotor activity and food intake to restricted feeding. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:20390056, 研究期間(年度):2008–2011 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「食餌同期性概日リズムを刻む視床下部背内側核ニューロンの機能解析」課題番号20390056 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390056/20390056seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=20296552 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390056/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390056/20390056seika/ |