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The role of nuclear pore complex in tumor microenvironment and metastasis
https://doi.org/10.24517/00039993
https://doi.org/10.24517/00039993273aa5a8-294b-4be1-9ea5-0ac5d9822330
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FR-PR-FUNASAKA-T-239.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-10-06 | |||||||
| タイトル | ||||||||
| タイトル | The role of nuclear pore complex in tumor microenvironment and metastasis | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00039993 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Funasaka, Tatsuyoshi
× Funasaka, Tatsuyoshi× Wong, Richard W. |
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| 著者別表示 |
船坂, 龍善
× 船坂, 龍善
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学フロンティアサイエンス機構 | |||||||
| 書誌情報 |
Cancer and Metastasis Reviews 巻 30, 号 2, p. 239-251, 発行日 2011-06-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0167-7659 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA10673193 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1007/s10555-011-9287-y | |||||||
| 出版者 | ||||||||
| 出版者 | Springer Science+Business Media, LLC | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | One of the main reasons for cancer mortality is caused by the highly invasive behavior of cancer cells, which often due to aggressive metastasis. Metastasis is mediated by various growth factors and cytokines, operating through numerous signaling pathways. Remarkably, all these metastatic signaling pathways must enter the nucleus through a single gatekeeper, the nuclear pore complex (NPC). NPCs are the only gateway between the cytoplasm and the nucleus. NPCs are among the largest proteinaceous assemblies in the cell and are composed of multiple copies of around 30 different proteins called nucleoporins. Here, we review what is currently known about the NPC, and its role in the mechanisms of tumor progression. We will also explore potential strategies to target metastatic pathways by manipulating the karyopherins (importins/exportins) of nucleocytoplasmic traffic through NPCs. © 2011 Springer Science+Business Media, LLC. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
