{"_buckets": {"deposit": "cd2b7688-e950-4080-9de1-c21483fce319"}, "_deposit": {"created_by": 3, "id": "42040", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "42040"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00042040", "sets": ["1135"]}, "author_link": ["66436", "66437", "22059", "66439", "66438", "81177", "66434", "66435"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "32", "bibliographicPageStart": "21", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{"bibliographic_title": "臨床薬理 = Japanese journal of clinical pharmacology and Therapeutics"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宮本, 謙一"}], "nameIdentifiers": [{"nameIdentifier": "81177", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30100514"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aims: Unpito, an herbal medicine extracted from a mixture of five crude medicines (Rhei Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber), has been developed as a drug for chronic renal failure. In general, it is difficult to estimate the absorption and excretion of herbal medicines due to the presence of a wide variety of components. The purpose of the current study was to examine the systemic pharmacokinetics and elimination of Unpito in healthy volunteers as part of the clinical study of the medicine. Methods: Three compounds, (-)epicatechin 3-O-gallate (ECG), glycyrrhetic acid (GA) and rhein (RH) were selected as markers, to examine the clinical pharmacokinetics of Unpito based on their levels in this medicine. The disposition of each compound was evaluated in 32 healthy volunteers receiving single oral doses (2, 4, 8, and 12 capsules). Results: After a single oral administration, ECG and RH exhibited linear pharmacokinetics in AUC and C max, while GA did not exhibit linear pharmacokinetics. A cross-over study was conducted to evaluate the effect of food at a single dose of 4 capsules. The effect of food was observed for the plasma concentrations of ECG and RH, while not for GA. The potential accumulations of δ-(3,4- dihydroxyphenyl)-γ-valerolactone (VL-2), a metabolite of ECG and RH were not observed. GA was not detected in urine. Conclusions: This is the first study presenting pharmacokinetics of ECG, GA and RH derived from Unpito, an herbal medicine, in healthy volunteers after single dose administration.", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "出版者照会後に全文公開", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00042027", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本臨床薬理学会 = The Japanese Society of Clinical Pharmacology and Therapeutics"}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jscpt.jp/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://sciencelinks.jp/j-east/article/200607/000020060706A0158304.php", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2006 日本臨床薬理学会"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN0025404X", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0388-1601", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takizawa, Yukiho"}], "nameIdentifiers": [{"nameIdentifier": "66434", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuhara, Yasuharu"}], "nameIdentifiers": [{"nameIdentifier": "66435", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Toshimi"}], "nameIdentifiers": [{"nameIdentifier": "66436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kase, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "66437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "66438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aburada, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "66439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyamoto, Ken-ichi"}], "nameIdentifiers": [{"nameIdentifier": "22059", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030100514"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-12-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-MIYAMOTO-K-21.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "PH-PR-MIYAMOTO-K-21.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/42040/files/PH-PR-MIYAMOTO-K-21.pdf"}, "version_id": "4867025d-9332-4c23-ac6b-d0fd6d72da61"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Clinical pharmacokinetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TJ-8117", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Unpito", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Healthy male volunteers", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Single dose", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": "https://doi.org/10.24517/00042027", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-12-27"}, "publish_date": "2018-12-27", "publish_status": "0", "recid": "42040", "relation": {}, "relation_version_is_last": true, "title": ["Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure"], "weko_shared_id": 3}