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In general, it is difficult to estimate the absorption and excretion of herbal medicines due to the presence of a wide variety of components. The purpose of the current study was to examine the systemic pharmacokinetics and elimination of Unpito in healthy volunteers as part of the clinical study of the medicine. Methods: Three compounds, (-)epicatechin 3-O-gallate (ECG), glycyrrhetic acid (GA) and rhein (RH) were selected as markers, to examine the clinical pharmacokinetics of Unpito based on their levels in this medicine. The disposition of each compound was evaluated in 32 healthy volunteers receiving single oral doses (2, 4, 8, and 12 capsules). Results: After a single oral administration, ECG and RH exhibited linear pharmacokinetics in AUC and C max, while GA did not exhibit linear pharmacokinetics. A cross-over study was conducted to evaluate the effect of food at a single dose of 4 capsules. The effect of food was observed for the plasma concentrations of ECG and RH, while not for GA. The potential accumulations of δ-(3,4- dihydroxyphenyl)-γ-valerolactone (VL-2), a metabolite of ECG and RH were not observed. GA was not detected in urine. 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{"creatorNames": [{"creatorName": "Mizuhara, Yasuharu"}], "nameIdentifiers": [{"nameIdentifier": "66435", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Toshimi"}], "nameIdentifiers": [{"nameIdentifier": "66436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kase, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "66437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "66438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aburada, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "66439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyamoto, Ken-ichi"}], "nameIdentifiers": [{"nameIdentifier": "22059", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030100514"}]}]}, "item_files": {"attribute_name": 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "Single dose", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": 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  1. D. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. d 10. 学術雑誌掲載論文(医・保健)
  3. 2.査読済論文(薬)

Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure

https://doi.org/10.24517/00042027
https://doi.org/10.24517/00042027
b3a6e269-37fd-48ed-908c-5fecf83ac58d
名前 / ファイル ライセンス アクション
PH-PR-MIYAMOTO-K-21.pdf PH-PR-MIYAMOTO-K-21.pdf (1.0 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-12-27
タイトル
タイトル Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00042027
ID登録タイプ JaLC
著者 Takizawa, Yukiho

× Takizawa, Yukiho

WEKO 66434

Takizawa, Yukiho

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Mizuhara, Yasuharu

× Mizuhara, Yasuharu

WEKO 66435

Mizuhara, Yasuharu

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Morita, Toshimi

× Morita, Toshimi

WEKO 66436

Morita, Toshimi

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Kase, Yoshihiro

× Kase, Yoshihiro

WEKO 66437

Kase, Yoshihiro

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Takeda, Shuichi

× Takeda, Shuichi

WEKO 66438

Takeda, Shuichi

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Aburada, Masaki

× Aburada, Masaki

WEKO 66439

Aburada, Masaki

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Miyamoto, Ken-ichi

× Miyamoto, Ken-ichi

WEKO 22059
研究者番号 30100514

Miyamoto, Ken-ichi

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著者別表示 宮本, 謙一

× 宮本, 謙一

WEKO 81177
e-Rad 30100514

宮本, 謙一

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書誌情報 臨床薬理 = Japanese journal of clinical pharmacology and Therapeutics

巻 37, 号 1, p. 21-32, 発行日 2006-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0388-1601
NCID
収録物識別子タイプ NCID
収録物識別子 AN0025404X
出版者