| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-22 |
| タイトル |
|
|
タイトル |
Enzalutamide versus abiraterone as a first-line endocrine therapy for castration-resistant prostate cancer (ENABLE study for PCa): A study protocol for a multicenter randomized phase III trial |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00049517 |
|
ID登録タイプ |
JaLC |
| 著者 |
Izumi, Kouji
Mizokami, Atsushi
Namiki, Mikio
Inoue, Shogo
Tanaka, Nobumichi
Yoshio, Yuko
Ishibashi, Kei
Kamiyama, Manabu
Kawai, Noriyasu
Enokida, Hideki
Shima, Takashi
Takahara, Shizuko
|
| 著者別表示 |
泉, 浩二
溝上, 敦
並木, 幹夫
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院泌尿器科 |
| 書誌情報 |
BMC Cancer
巻 17,
号 1,
p. 677,
発行日 2017-10-10
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1471-2407 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1186/s12885-017-3661-2 |
| 出版者 |
|
|
出版者 |
BioMed Central Ltd. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Both enzalutamide and abiraterone have demonstrated improved radiographic progression-free and overall survival for castration-resistant prostate cancer (CRPC) compared with placebo controls before docetaxel treatment in phase III studies. These oral agents target androgen and androgen receptor signaling and are thought to be less toxic than chemotherapy. Cross-resistance to these agents was recently reported because of their similar mechanism of action, and it is important to assess which agent is more effective to use initially for CRPC. Methods/design: The present study is a phase III, investigator-initiated, multicenter, head-to-head, randomized controlled trial investigating enzalutamide vs. abiraterone as a first-line treatment for CRPC patients. Patients will be randomly assigned to an enzalutamide or an abiraterone treatment group. The primary endpoint is the time to prostate-specific antigen progression. The target sample size is set at 100 patients per group (total, 200 patients). The study duration is 5 years, and the duration for recruitment is 2 years and 6 months. Discussion: Thus far, there have been no prospective head-to-head studies comparing enzalutamide and abiraterone. This ENABLE study will clarify which agent should be prioritized for CRPC patients and enable clinicians to decide the appropriate treatment before chemotherapy. Trial registration: University hospital Medical Information Network (UMIN) Center identifier UMIN000015529. Registrated 11/1/2014. © 2017 The Author(s). |
| 権利 |
|
|
権利情報 |
Copyright © author |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
HO-PR-IZUMI-K-677.pdf (588.8 kB)
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