| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-22 |
| タイトル |
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|
タイトル |
Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00049541 |
|
ID登録タイプ |
JaLC |
| 著者 |
Oka, Rie
Shibata, Kyoko
Sakurai, Masaru
Kometani, Mitsuhiro
Yamagishi, Masakazu
Yoshimura, Kenichi
Yoneda, Takashi
|
| 著者別表示 |
大家, 理恵
柴田, 恭子
櫻井, 勝
米谷, 充弘
山岸, 正和
吉村, 健一
米田, 隆
|
| 提供者所属 |
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|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院研修医・専門医総合教育センター |
| 書誌情報 |
Journal of Diabetes Research
巻 2017,
p. 5307523,
発行日 2017-09-14
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2314-6745 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1155/2017/5307523 |
| 出版者 |
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出版者 |
Hindawi Limited |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. © 2017 Rie Oka et al. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 権利 |
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|
権利情報 |
Copyright © 2017 Rie Oka et al. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
HO-PR-KOMETAN-M-5307523.pdf (903.3 kB)
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