| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-22 |
| タイトル |
|
|
タイトル |
A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00049542 |
|
ID登録タイプ |
JaLC |
| 著者 |
Sugitani, Kayo
Koriyama, Yoshiki
Sera, Mayuko
Arai, Kunizo
Ogai, Kazuhiro
Wakasugi, Keisuke
|
| 著者別表示 |
杉谷, 加代
郡山, 恵樹
荒井, 國三
大貝, 和裕
若杉, 桂輔
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域保健学系 |
| 書誌情報 |
Biochemical and Biophysical Research Communications
巻 493,
号 3,
p. 1254-1259,
発行日 2017-11-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbrc.2017.09.127 |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Neuroglobin (Ngb) is a recently discovered heme protein in the vertebrate brain that can bind to oxygen molecules. Mammalian Ngb plays a crucial role in neuroprotection under conditions of oxidative stress. To investigate other potential functions of Ngb, we investigated the mouse retinal Ngb system following optic nerve injury. In the retina of control mice, Ngb immunoreactivity was limited to the retinal ganglion cell (RGC) layer, and this immunoreactivity rapidly decreased to less than 50% of the control level 5 days after optic nerve injury. On the basis of this decrease, we designed in vivo experiments with enhanced expression of Ngb using adult mouse retina. The enhanced expression of Ngb was achieved by injecting chimeric human Ngb protein, which included the cell membrane-penetrating module of fish Ngb. One-day pretreatment with chimeric Ngb increased immunoreactivity levels of Ngb two-fold in mouse RGCs and increased the number of surviving RGCs three-fold by 14 days after optic nerve injury compared with vehicle controls. Furthermore, in the mouse retinas showing enhanced Ngb expression, several regenerating central optic axons exhibited outgrowth and were found to pass through the nerve crush site 14 days after nerve injury. No such regenerating optic axons were observed in the control mouse optic nerve during the same time frame. The data obtained from in vivo experiments strongly indicate that mammalian Ngb has neuroprotective and neuroregenerative properties. © 2017 Elsevier Inc. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 権利 |
|
|
権利情報 |
Copyright © 2017 Elsevier Inc.(CC-BY NC ND) |
| 権利 |
|
|
権利情報 |
http://www.elsevier.com/locate/issn/0006291X |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ME-PR-SUGITANI-K-1254.pdf (622.7 kB)
.png)
