| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-04-06 |
| タイトル |
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|
タイトル |
A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00050483 |
|
ID登録タイプ |
JaLC |
| 著者 |
Xu, Liang
Nagata, Naoto
Nagashimada, Mayumi
Zhuge, Fen
Ni, Yinhua
Chen, Guanliang
Kamei, Junzo
Ishikawa, Hiroki
Komatsu, Yasuhiko
Kaneko, Shuichi
Ota, Tsuguhito
|
| 著者別表示 |
長田, 直人
金子, 周一
太田, 嗣人
|
| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Oncotarget
巻 9,
号 19,
p. 15047-15060,
発行日 2018
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1949-2553 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.18632/oncotarget.24587 |
| 出版者 |
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出版者 |
Impact Journals LLC |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Nonalcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver. NAFLD is associated with hepatic inflammation and oxidative stress, resulting in nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Placental extracts have been used to treat various chronic diseases due to their antioxidative effect. However, the effects of the extracts on the development of NASH have yet to be elucidated. Here, we demonstrated that supplementation with an oral porcine placental extract (PPE) attenuated lipid accumulation and peroxidation, insulin resistance, inflammatory and stress signaling, and fibrogenesis in the liver of NASH model mice fed a high-cholesterol and high-fat diet. The PPE reduced the number of M1-like liver macrophages, but increased the number of anti-inflammatory M2-like macrophages, resulting in a predominance of M2 over M1 macrophage populations in the liver of NASH mice. Accordingly, the PPE suppressed lipopolysaccharide-induced M1 polarization in isolated murine peritoneal macrophages, whereas it facilitated interleukin 4-induced M2 polarization. Furthermore, the PPE reduced the hepatic stellate cell (HSC) activation associated with the attenuated transforming growth factor-β/Smad3 signaling, both in the liver of NASH mice and in RI-T cells, a HSC line. The PPE may be a potential approach to prevent NASH by limiting lipid peroxidation, promoting M2 macrophage polarization, and attenuating HSC activation. © Xu et al. |
| 権利 |
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|
権利情報 |
Copyright © Xu et al. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ME-PR-NAGATA-N-15047.pdf (1.0 MB)
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