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Detection of CCND1 gene copy number variations using multiplex ligation-dependent probe amplification and fluorescence in situ hybridization methods
https://doi.org/10.24517/00050498
https://doi.org/10.24517/000504989396c4a7-312b-4016-a462-3d1ae92b6127
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-OOI-A-101.pdf (208.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2018-04-13 | |||||||||
| タイトル | ||||||||||
| タイトル | Detection of CCND1 gene copy number variations using multiplex ligation-dependent probe amplification and fluorescence in situ hybridization methods | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00050498 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Ooi, Akishi
× Ooi, Akishi× Oyama, Takeru |
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| 著者別表示 |
大井, 章史
× 大井, 章史
× 尾山, 武
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Methods in Molecular Biology 巻 1726, p. 101-109, 発行日 2018-02-22 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1064-3745 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11067778 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1007/978-1-4939-7565-5_10 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Humana Press Inc. / Springer | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The CCND1 locus is located in 11q13 and encodes the G1–S regulatory protein, cyclin D1. Cyclin D1 is frequently amplified in various types of cancers, and is an attractive potential therapeutic target. Multiplex ligation-dependent probe amplification (MLPA) is a new, high-resolution method for the detection of amplification of numerous genes including CCND1 in small amounts of DNA fragments derived from formalin-fixed, paraffin-embedded material in a single reaction. This approach is, however, based on PCR and averages many different cells, so validation by morphological methods such as fluorescence in situ hybridization (FISH) is theoretically mandatory. Here we describe detection of CCND1 gene copy number variations by commercially available MLPA kits and FISH using a bacterial artificial chromosome (BAC) probe. © Springer Science+Business Media, LLC 2018. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Embargo Period 12 months | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright © Springer Science+Business Media, LLC 2018. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/10643745 | |||||||||
| 関連名称 | http://www.elsevier.com/locate/issn/10643745 | |||||||||
