Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2018-04-23 |
タイトル |
|
|
タイトル |
Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes |
言語 |
|
|
言語 |
eng |
資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
ID登録 |
|
|
ID登録 |
10.24517/00050597 |
|
ID登録タイプ |
JaLC |
著者 |
Furuichi, Kengo
Yuzawa, Yukio
Shimizu, Miho
Hara, Akinori
Toyama, Tadashi
Kitamura, Hiroshi
Suzuki, Yoshiki
Sato, Hiroshi
Uesugi, Noriko
Ubara, Yoshifumi
Hisano, Satoshi
Ueda, Yoshihiko
Nishi, Shinichi
Yokoyama, Hitoshi
Nishino, Tomoya
Kohagura, Kentaro
Ogawa, Daisuke
Mise, Koki
Shibagaki, Yugo
Kimura, Kenjiro
Haneda, Masakazu
Makino, Hirofumi
Matsuo, Seiichi
Wada, Takashi
|
著者別表示 |
古市, 賢吾
清水, 美保
原, 章規
遠山, 直志
和田, 隆志
|
提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
書誌情報 |
Nephrology Dialysis Transplantation
巻 33,
号 1,
p. 138-148,
発行日 2018-01-01
|
ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0931-0509 |
NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1073277X |
DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/ndt/gfw417 |
出版者 |
|
|
出版者 |
Oxford University Press |
抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background. The clinical and pathologic manifestations of nephropathy due to type 2 diabetes are diverse, but large-scale pathologic studies with long-termobservations are limited. Methods. Kidney biopsies and clinical data of 600 patients with type 2 diabetes were collected retrospectively from 13 centres across Japan. Thirteen pathologic findings (nine glomerular lesions, two interstitial lesions and two vascular lesions) were clearly defined and scored. Results. During the observation period, there were 304 composite kidney events [dialysis, doubling of creatinine or reduction of estimated glomerular filtration rate (eGFR) by half], 31 instances of chronic kidney disease (CKD) G5D, 76 cardiovascular events and 73 deaths. The mean observation period was 72.4 months. The distribution of CKD heat map categories for the 600 patients was 103 green or yellow, 149 orange and 348 red. Even in the cases in the green and yellow category, diffuse lesions (81.6%), polar vasculosis (42.6%) and subendothelial space widening (35.1%) were commonly detected. Cox proportional hazard analysis revealed that the presence of nodular lesions [hazard ratio (HR) 21.1, 95% confidence interval (CI) 5.3-84.6], exudative lesions (HR 5.1, 95% CI 1.3-20.3) and mesangiolysis (HR 7.6, 95% CI 2.0-28.8) in cases in the green and yellow category were associated with significantly great impact on composite kidney events after adjustment for clinical risk factors. Conclusions. This nationwide study on kidney biopsy of 600 cases with type 2 diabetes revealed that pathologic findings (presence of nodular lesions, exudative lesions and mesangiolysis) were strong predictors of kidney events in low-risk patients. © The Author 2017. |
内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
権利 |
|
|
権利情報 |
Copyright © The Author 2017. |
著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |