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Clustering of metabolic syndrome components attenuates coronary plaque regression during intensive statin therapy in patients with acute coronary syndrome: The JAPAN-ACS subanalysis study
https://doi.org/10.24517/00050642
https://doi.org/10.24517/00050642e6ba18c3-9bca-4a18-ac67-2b3e1792fcfb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YAMAGISHI-M-2840.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2018-03-23 | |||||||
| タイトル | ||||||||
| タイトル | Clustering of metabolic syndrome components attenuates coronary plaque regression during intensive statin therapy in patients with acute coronary syndrome: The JAPAN-ACS subanalysis study | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00050642 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Takashima, Hiroaki
× Takashima, Hiroaki× Ozaki, Yukio× Morimoto, Takeshi× Kimura, Takeshi× Hiro, Takafumi× Miyauchi, Katsumi× Nakagawa, Yoshihisa× Yamagishi, Masakazu× Daida, Hiroyuki× Mizuno, Tomofumi× Asai, Kenji× Kuroda, Yasuo× Kosaka, Takashi× Kuhara, Yasushi× Kurita, Akiyoshi× Maeda, Kazuyuki× Amano, Tetsuya× Matsuzaki, Masunori |
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| 著者別表示 |
山岸, 正和
× 山岸, 正和
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Circulation Journal 巻 76, 号 12, p. 2840-2847, 発行日 2012 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1346-9843 | |||||||
| NCID | ||||||||
| 識別子タイプ | NCID | |||||||
| 関連識別子 | BA81861067 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1253/circj.CJ-11-1495 | |||||||
| 出版者 | ||||||||
| 出版者 | Japanese Circulation Society = 日本循環器学会 | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: The JAPAN-ACS (Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome) trial showed that intensive statin therapy could induce significant coronary plaque regression in acute coronary syndrome (ACS). We evaluated the impact of metabolic syndrome (MetS) and its components on coronary plaque regression in the JAPAN-ACS patients. Methods and Results: Serial intravascular ultrasound measurements over 8-12 months were performed in 242 ACS patients receiving pitavastatin or atorvastatin. Patients were divided into groups according to the presence of MetS or the number of MetS components. Although the percent change in plaque volume (%PV) was not significantly different between the MetS (n=119) and non-MetS (n=123) groups (P=0.50), it was significantly associated with an increasing number of MetS components (component 0: -24.0%, n=7; components 1: -20.8%, n=31; components 2: -16.1%, n=69; components 3: -18.7%, n=83; components 4: -13.5%, n=52; P=0.037 for trend). The percent change in body mass index (%BMI) significantly correlated with %PV (r=0.15, P=0.021), especially in the MetS components 4 group (r=0.35, P=0.017). In addition, %BMI was an independent predictor of plaque regression after adjustment for the changes of low- and high-density lipoprotein cholesterol, triglycerides and HbA1c. Conclusions: The clustering of MetS components, but not the presence of MetS itself, could attenuate coronary plaque regression during intensive statin therapy in ACS patients. Therefore, to achieve a greater degree of plaque regression, it is necessary to treat to each MetS component and use lifestyle modification. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 出版者照会後に全文公開 | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Japanese Circulation Society 日本循環器学会 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.j-circ.or.jp/ | |||||||
| 関連名称 | http://www.j-circ.or.jp/ | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/circj/-char/en | |||||||
| 関連名称 | https://www.jstage.jst.go.jp/browse/circj/-char/en | |||||||
