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Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: A retrospective multicenter study
https://doi.org/10.24517/00050648
https://doi.org/10.24517/0005064851c38b36-e80d-49dc-850d-3169925c3b9c
名前 / ファイル | ライセンス | アクション |
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ME-PR-YAMAGISHI-M-R156.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-27 | |||||
タイトル | ||||||
タイトル | Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: A retrospective multicenter study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050648 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Mizushima, Ichiro
× Mizushima, Ichiro× Inoue, Dai× Yamamoto, Motohisa× Yamada, Kazunori× Saeki, Takako× Ubara, Yoshifumi× Matsui, Shoko× Masaki, Yasufumi× Wada, Takashi× Kasashima, Satomi× Harada, Kenichi× Takahashi, Hiroki× Notohara, Kenji× Nakanuma, Yasuni× Umehara, Hisanori× Yamagishi, Masakazu× Kawano, Mitsuhiro |
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著者別表示 |
水島, 伊知郎
× 水島, 伊知郎× 井上, 大× 山田, 和徳× 和田, 隆志× 笠島, 里美× 原田, 憲一× 中沼, 安二× 梅原, 久範× 山岸, 正和× 川野, 充弘 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Arthritis Research and Therapy 巻 16, 号 4, p. R156, 発行日 2014-07-23 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1478-6354 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11830978 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/ar4671 | |||||
出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Immunoglobulin G4 (IgG4)-related aortitis/periaortitis and periarteritis are vascular manifestations of IgG4-related disease. In this disease, the affected aneurysmal lesion has been suspected to be at risk of rupture. In this study, we aimed to clarify the clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis.Methods: We retrospectively evaluated clinical features, including laboratory data, imaging findings and the course after corticosteroid therapy, in 40 patients diagnosed with IgG4-related aortitis/periaortitis and periarteritis on the basis of periaortic/periarterial radiological findings, satisfaction of the comprehensive diagnostic criteria or each organ-specific diagnostic criteria, and exclusion of other diseases. Results: The patients were mainly elderly, with an average age of 66.4 years and with a marked male predominance and extensive other organ involvement. Subjective symptoms were scanty, and only a small proportion had elevated serum C-reactive protein levels. The affected aorta/artery were the abdominal aortas or the iliac arteries in most cases. Thirty-six patients were treated with prednisolone, and the periaortic/periarterial lesions improved in most of them during the follow-up period. Two (50.0%) of four patients with luminal dilatation of the affected lesions before corticosteroid therapy had exacerbations of luminal dilatation after therapy, whereas none of the twenty-six patients without it had a new appearance of luminal dilatation after therapy. Conclusions: The results of this retrospective multicenter study highlight three important points: (1) the possibility of latent existence and progression of periaortic/periarterial lesions, (2) the efficacy of corticosteroid therapy in preventing new aneurysm formation in patients without luminal dilatation of periaortic/periarterial lesions and (3) the possibility that a small proportion of patients may actually develop luminal dilatation of periaortic/periarterial lesions in IgG4-related aortitis/periaortitis and periarteritis. A larger-scale prospective study is required to confirm the efficacy and safety of corticosteroid therapy in patients with versus those without luminal dilatation and to devise a more useful and safe treatment strategy, including administration of other immunosuppressants. © 2014 Mizushima et al.; licensee BioMed Central Ltd. | |||||
権利 | ||||||
権利情報 | Copyright © BioMed Central Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |