| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-04-27 |
| タイトル |
|
|
タイトル |
Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00050665 |
|
ID登録タイプ |
JaLC |
| 著者 |
Tagawa, Shotoku
Nakanishi, Chiaki
Mori, Masayuki
Yoshimuta, Tsuyoshi
Yoshida, Shohei
Shimojima, Masaya
Yokawa, Junichiro
Kawashiri, Masa-aki
Yamagishi, Masakazu
Hayashi, Kenshi
|
| 著者別表示 |
田川, 庄督
中西, 千明
吉牟田, 剛
吉田, 昌平
川尻, 剛照
山岸, 正和
林, 研至
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
International Journal of Vascular Medicine
巻 2015,
p. 674213,
発行日 2015
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2090-2824 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1155/2015/674213 |
| 出版者 |
|
|
出版者 |
Hindawi Publishing Corporation |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The clinical implications of early and late endothelial progenitor cells (EPCs) in coronary artery disease (CAD) remain unclear. We investigated endothelial dysfunction in CAD by simultaneously examining early and late EPC colony formation and gene expression of specific surface markers in EPCs. EPCs were extracted from a total of 83 subjects with (n=47) and without (n=36) CAD. Early and late EPC colonies were formed from mononuclear cells extracted from peripheral blood. We found that fewer early EPC colonies were produced in the CAD group (7.2 ± 3.l/well) than those in the control group (12.4 ± 1.4/well, p<0.05), and more late EPC colonies were produced in the CAD group (0.8 ± 0.2/well) than those in the control group (0.25 ± 0.02/well, p<0.05). In the CAD group, the relative expression of CD31 and KDR of early and late EPCs was lower than in the control group. These results demonstrate that CAD patients could have increased late EPC density and that early and late EPCs in CAD patients exhibited immature endothelial characteristics. We suggest that changes in EPC colony count and gene expression of endothelial markers may have relation with development of CAD. © 2015 Shotoku Tagawa et al. |
| 権利 |
|
|
権利情報 |
Copyright © Hindawi Publishing Corporation |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ME-PR-YAMAGISHI-M-674213.pdf (3.2 MB)
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