| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-17 |
| タイトル |
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|
タイトル |
Near-Infrared fluorescence imaging directly visualizes lymphatic drainage pathways and connections between superficial and deep lymphatic systems in the mouse hindlimb |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00050751 |
|
ID登録タイプ |
JaLC |
| 著者 |
Nakajima, Yukari
Asano, Kimi
Mukai, Kanae
Urai, Tamae
Okuwa, Mayumi
Sugama, Junko
Nakatani, Toshio
|
| 著者別表示 |
中島, 由加里
向井, 加奈恵
大桑, 麻由美
須釜, 淳子
中谷, 壽男
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域 |
| 書誌情報 |
en : Scientific Reports
巻 8,
p. 7078,
発行日 2018-05-04
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2045-2322 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/s41598-018-25383-y |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Since lymphedema rarely develops in the mouse hindlimb, the underlying mechanisms remain unclear. We herein investigated the resolution of chronic hindlimb lymphedema in mice using a Near-Infrared Fluorescence (NIRF) imaging system. Nineteen 7–28-week-old BALB/c male and female mice were injected with two dyes for lymphography and dissection. Lymphadenectomy was performed on six male mice to completely obstruct lymph flow in the hindlimb. Edematous changes in both hindlimbs were compared until 60 days after surgery. The NIRF imaging system detected three lymphatic collecting systems in the mouse hindlimb: superficial lateral, superficial medial, and deep medial. It also showed connections between the superficial and deep lymphatic systems in the inguinal region. Lymphadenectomy of the iliac, inguinal, and popliteal lymph nodes caused edematous changes. However, lymph flow in these operated areas restarted within 60 days and the severity of lymphedema appeared to be low. NIRF imaging showed that the deep medial system and a connection between the superficial and deep lymphatic systems in the inguinal region drain lymph from the hindlimb. This is the one reasons why lymphedema does not develop in the mouse hindlimb. The stable obstruction of lymph flow in these three systems is desired to develop chronic lymphedema. |
| 権利 |
|
|
権利情報 |
Copyright © Nature Publishing Group |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.nature.com/articles/s41598-018-25383-y |
|
|
関連名称 |
http://www.nature.com/articles/s41598-018-25383-y |
ME-PR-NAKATANI-T-7078.pdf (1.6 MB)
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