| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-17 |
| タイトル |
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|
タイトル |
Does obesity without hyperglycemia delay wound healing in an obese mouse model induced by a high-fat diet? |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00050752 |
|
ID登録タイプ |
JaLC |
| 著者 |
Urai, Tamae
Nakajima, Yukari
Mukai, Kanae
Asano, Kimi
Okuwa, Mayumi
Sugama, Junko
Nakatani, Toshio
|
| 著者別表示 |
中島, 由加里
向井, 加奈恵
大桑, 麻由美
須釜, 淳子
中谷, 壽男
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域 |
| 書誌情報 |
en : Health
巻 9,
号 12,
p. 1660-1679,
発行日 2017-11-29
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1949-4998 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.4236/health.2017.912122 |
| 出版者 |
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出版者 |
Scientific Research Publishing |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels. |
| 権利 |
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|
権利情報 |
Copyright © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://file.scirp.org/Html/5-8204158_80668.htm |
|
|
関連名称 |
http://file.scirp.org/Html/5-8204158_80668.htm |
ME-PR-NAKATANI-T-1660.pdf (1.8 MB)
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