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Modeling immunotherapy and outcomes in acute myeloid leukemia
https://doi.org/10.24517/00051446
https://doi.org/10.24517/0005144635c5073a-8d1d-424c-bdae-2c52fd8d28a0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Sci_Rep_61-25-38 (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-03 | |||||
| タイトル | ||||||
| タイトル | Modeling immunotherapy and outcomes in acute myeloid leukemia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | acute myeloid leukemia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | computational model | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | regulatory T cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | bistability | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | relapse free survival curve | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00051446 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
Nishiyama, Yoshiaki
× Nishiyama, Yoshiaki× Nishiyama, Nobuaki |
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| 著者別表示 |
西山, 宣昭
× 西山, 宣昭 |
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| 書誌情報 |
The Science Reports of Kanazawa University en : The Science Reports of Kanazawa University 巻 61, p. 25-38, 発行日 2017 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2433-040X | |||||
| 出版者 | ||||||
| 出版者 | Institute of Science and Engineering, Kanazawa University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Very recently, we proposed an ordinary differential equation model incorporating promotion of regulatory T cell (Tregs) expansion by leukemic cells, which describes co-evolutional dynamics between leukemic and immune cells in progression of acute myeloid leukemia (AML). To evaluate the ability of our model to predict effectiveness of immunotherapy for AML, we performed Monte Carlo simulation of trajectories in phase plane and generated relapse free survival (RFS) curves, which could be compared with clinical data. The resulting RFS curves were in good accordance with clinical outcomes reported in immunotherapies of NK cells infusion with/without Tregs depletion. In addition, our simulation results focusing on consecutive cycles of cell infusion with/without cell depletion qualitatively accounts for the effectiveness of corresponding clinical immunotherapy. The present results suggest that our model may provide valuable information for future design of immunotherapy in AML. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://scirep.w3.kanazawa-u.ac.jp/ | |||||
