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腎コロボーマ症候群特異的iPS細胞による腎臓病の病態解明
https://doi.org/10.24517/00051540
https://doi.org/10.24517/00051540b5ba648a-603e-4bde-9bff-18718f3cd2d9
名前 / ファイル | ライセンス | アクション |
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HO-PR-FURUICHI-K-kaken 2017-5p.pdf (177.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-07-06 | |||||
タイトル | ||||||
タイトル | 腎コロボーマ症候群特異的iPS細胞による腎臓病の病態解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathophysiological analysis using iPS cells from patient with Renal Coloboma syndrome | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051540 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Furuichi, Kengo
× Furuichi, Kengo |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院血液浄化療法部 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2015-04-01 - 2017-03-31, p. 5p., 発行日 2017-06-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本課題は,稀少遺伝性疾患である,PAX2遺伝子変異を伴った腎コロボーマ症候群から疾患特異iPS細胞を樹立し,本症候群の病態解明,治療法開発および薬剤スクリーニングシステムを構築するものである. PAX2遺伝子変異を伴った3例の腎コロボーマ症候群症例の血球細胞からiPS細胞およびコントロールの健常日本人由来iPS細胞から中間中胚葉および尿細管などの腎系譜細胞への誘導を確立した.また,腎系譜細胞へ誘導された経時的なサンプルから、候補遺伝子に対する経時的発現遺伝子解析を行い,PAX2の遺伝子発現と呼応して発現増強し,疾患特異iPS細胞で発現増強の低減が見られる因子群を確認した. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we established disease-specific iPS cells from renal coloboma syndrome with PAX2 gene mutation, which is a rare genetic disorder. To clarify the pathogenesis of this syndrome, we used these iPS cells. The cells were also used to investigate therapeutic target genes. We induced kidney lineage cells, such as mesoderm and renal tubules, from disease-specific and control iPS cells. In addition, time-sequential expression gene analysis was performed. Some gene expressions were enhanced in response to gene expression of PAX2, and some candidate genes in which expression was reduced in disease specific iPS cells was detected. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K15328, 研究期間(年度):2015-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「腎コロボーマ症候群特異的iPS細胞による腎臓病の病態解明」研究成果報告書 課題番号15K15328 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15328/15K15328seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=50432125 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=50432125 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15328/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15328/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15328/15K15328seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15328/15K15328seika/ |