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白金錯体の非共有性相互作用に基づく抗がん活性解明と創薬化
https://doi.org/10.24517/00051678
https://doi.org/10.24517/000516784d6a628f-82bd-4a6e-8350-7e351ecc2016
名前 / ファイル | ライセンス | アクション |
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PH-PR-ODANI-A-kaken 2017-6p.pdf (157.7 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-07-19 | |||||
タイトル | ||||||
タイトル | 白金錯体の非共有性相互作用に基づく抗がん活性解明と創薬化 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Study of anticancer Pt complexes involving with non-covalent interactions and its application for drug | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051678 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Odani, Akira
× Odani, Akira |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2013-04-01 - 2017-03-31, p. 6p., 発行日 2017-06-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 芳香環スタッキングを有する混合配位子白金錯体が臨床白金抗がん剤シスプラチンよりも高い抗がん活性,低い副作用を示した.リン酸基と白金配位アミン間の水素結合は骨へのデリバリー,低副作用化に有用であり,金属ポルフィリンと組み合わされた白金錯体は光により活性化され高いin vivo抗がん活性を示した.これらは相互作用が動的な生体過程で働いていることを示唆しており,非共有性相互作用の金属錯体への導入は創薬に有用なツールであった. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mixed ligand Pt complexes involving aromatic ring stacking revealed excellent antitumor effect and low side effect. The hydrogen bond between the phosphate and the amine was useful for bone delivery and low side effect. The Pt complexes with the metal-porphyrin showed pronounced antitumor effect activated by the light. These indicated the non-covalent interaction could play in dynamic biological process, and the introduction of non-covalent interaction into the metal complex is a useful tool for metal-drug application. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:25288027, 研究期間(年度):2013-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「白金錯体の非共有性相互作用に基づく抗がん活性解明と創薬化」研究成果報告書 課題番号25288027 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25288027/25288027seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=60143913 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=60143913 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25288027/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25288027/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25288027/25288027seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25288027/25288027seika/ |