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  1. C. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. c 10. 学術雑誌掲載論文(医・保健)
  3. 1. 査読済論文(医学・保健)

Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.

https://doi.org/10.24517/00053846
https://doi.org/10.24517/00053846
3b5e31cb-b5ba-4173-80bc-99fa5ca20c78
名前 / ファイル ライセンス アクション
ME-PR-MUNESUE-S-1944.pdf ME-PR-MUNESUE-S-1944.pdf (690.6 kB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-04-12
タイトル
タイトル Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00053846
ID登録タイプ JaLC
著者 Higuchi, Takashi

× Higuchi, Takashi

WEKO 24486
e-Rad 00728719

Higuchi, Takashi

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Takeuchi, Akihiko

× Takeuchi, Akihiko

WEKO 22247
e-Rad 70512218
金沢大学研究者情報 70512218
研究者番号 70512218

Takeuchi, Akihiko

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Munesue, Seiichi

× Munesue, Seiichi

WEKO 78962
e-Rad 10399040

Munesue, Seiichi

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Yamamoto, Norio

× Yamamoto, Norio

WEKO 22248
e-Rad 90332668
金沢大学研究者情報 90332668
研究者番号 90332668

Yamamoto, Norio

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Hayashi, Katsuhiro

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WEKO 22250
e-Rad 80507054
金沢大学研究者情報 80507054
研究者番号 80507054

Hayashi, Katsuhiro

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Kimura, Hiroaki

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WEKO 1347
e-Rad 60363074
金沢大学研究者情報 60363074
研究者番号 60363074

Kimura, Hiroaki

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Miwa, Shinji

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WEKO 21889
e-Rad 40753455

Miwa, Shinji

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Inaki, Hiroyuki

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Inaki, Hiroyuki

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Shimozaki, Shingo

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Shimozaki, Shingo

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Kato, Takashi

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Kato, Takashi

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Aoki, Yu

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Aoki, Yu

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Abe, Kensaku

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Abe, Kensaku

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Taniguchi, Yuta

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Aiba, Hisaki

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Aiba, Hisaki

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Murakami, Hideki

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金沢大学研究者情報 70334779
研究者番号 70334779

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Harashima, Ai

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Harashima, Ai

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Yamamoto, Yasuhiko

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Yamamoto, Yasuhiko

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Tsuchiya, Hiroyuki

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Tsuchiya, Hiroyuki

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著者別表示 武内, 章彦

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棟居, 聖一

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山本, 憲男

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林, 克洋

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林, 克洋

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三輪, 真嗣

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谷口, 裕太

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谷口, 裕太

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原島, 愛

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原島, 愛

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山本, 靖彦

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土屋, 弘行

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提供者所属
内容記述タイプ Other
内容記述 金沢大学医薬保健研究域医学系
書誌情報 Cancer Medicine

巻 7, 号 5, p. 1944-1954, 発行日 2018-05
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-7634
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1002/cam4.1438
出版者
出版者 Wiley-Blackwell
抄録
内容記述タイプ Abstract
内容記述 Surgical resection is the only treatment for chondrosarcomas, because of their resistance to chemotherapy and radiotherapy; therefore, additional strategies are crucial to treat chondrosarcomas. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor, which has been reported as a possible therapeutic target in certain malignancies including chondrosarcomas. In this study, we demonstrated that a nonsteroidal anti-inflammatory drug, zaltoprofen, could induce PPARγ activation and elicit anti-tumor effects in chondrosarcoma cells. Zaltoprofen was found to induce expressions of PPARγ mRNA and protein in human chondrosarcoma SW1353 and OUMS27 cells, and induce PPARγ-responsible promoter reporter activities. Inhibitory effects of zaltoprofen were observed on cell viability, proliferation, migration, and invasion, and the activity of matrix metalloproteinase-2 (MMP2); these effects were dependent on PPARγ activation and evidenced by silencing PPARγ. Moreover, we showed a case of a patient with cervical chondrosarcoma (grade 2), who was treated with zaltoprofen and has been free from disease progression for more than 2 years. Histopathological findings revealed enhanced expression of PPARγ and reduced expression of MMP2 after administration of zaltoprofen. These findings demonstrate that zaltoprofen could be a promising drug against the malignant phenotypes in chondrosarcomas via activation of PPARγ and inhibition of MMP2 activity. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
内容記述
内容記述タイプ Other
内容記述 29573200
権利
権利情報 Copyright © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連URI
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.1438
関連名称 https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.1438
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