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Activity-dependent visualization and control of neural circuits for courtship behavior in the fly Drosophila melanogaster
https://doi.org/10.24517/00053862
https://doi.org/10.24517/00053862260e43d8-6115-4d7b-9d52-a1155aa48dc8
| 名前 / ファイル | ライセンス | アクション |
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SC-PR-KIYA-T-5715.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2019-04-12 | |||||||||
| タイトル | ||||||||||
| タイトル | Activity-dependent visualization and control of neural circuits for courtship behavior in the fly Drosophila melanogaster | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00053862 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Takayanagi-Kiya, Seika
× Takayanagi-Kiya, Seika× Kiya, Taketoshi |
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| 著者別表示 |
木矢, 星歌
× 木矢, 星歌
× 木矢, 剛智
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学理工学研究域生命理工学系 | |||||||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America 巻 116, 号 12, p. 5715-5721, 発行日 2019-03-19 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0027-8424 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10808769 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1073/pnas.1814628116 | |||||||||
| 出版者 | ||||||||||
| 出版者 | National Academy of Sciences | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Males of Drosophila melanogaster exhibit stereotypic courtship behavior through which they assess potential mates by processing multimodal sensory information. Although previous studies revealed important neural circuits involved in this process, the full picture of circuits that participate in male courtship remains elusive. Here, we established a genetic tool to visualize or optogenetically reactivate neural circuits activated upon specific behavior, exploiting promoter activity of a neural activity-induced gene Hr38. With this approach, we visualized neural circuits activated in the male brain and the ventral nerve cord when a male interacted with a female. The labeling of neural circuits was additively dependent on inputs from antennae and foreleg tarsi. In addition, neural circuits that express the sex-determining gene fruitless or doublesex were extensively labeled by interaction with a female. Furthermore, optogenetic reactivation of the labeled neural circuits induced courtship posture. With this mapping system, we found that a fruitless-positive neural cluster aSP2 was labeled when a male interacted with a female, in addition to previously characterized neurons. Silencing of neurons including aSP2 led to frequent interruption of courtship and significant reduction of mating success rate without affecting latency to start courtship, suggesting that these neurons are required for courtship persistency important for successful copulation. Overall, these results demonstrate that activity-dependent labeling can be used as a powerful tool not only in vertebrates, but also in invertebrates, to identify neural circuits regulating innate behavior. © 2019 National Academy of Sciences. All Rights Reserved. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Embarogo Period 6 months | |||||||||
| 権利 | ||||||||||
| 権利情報 | copyright © National Academy of Sciences | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.pnas.org/content/116/12/5715 | |||||||||
| 関連名称 | https://www.pnas.org/content/116/12/5715 | |||||||||
