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Expression of Transcripts Selective for GABA Neuron Subpopulations across the Cortical Visuospatial Working Memory Network in the Healthy State and Schizophrenia
https://doi.org/10.24517/00053879
https://doi.org/10.24517/00053879509aed16-7180-4908-80fe-6629511b4c24
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-HASHIMOTO-T-3540.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2019-08-30 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Expression of Transcripts Selective for GABA Neuron Subpopulations across the Cortical Visuospatial Working Memory Network in the Healthy State and Schizophrenia | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.24517/00053879 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
Tsubomoto, Makoto
× Tsubomoto, Makoto× Kawabata, Rika× Zhu, Xiaonan× Minabe, Yoshio× Chen, Kehui× Lewis, David A.× Hashimoto, Takanori |
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| 著者別表示 |
坪本, 真
× 坪本, 真
× 川端, 梨加
× 三邉, 義雄
× 橋本, 隆紀
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| 提供者所属 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 金沢大学医薬保健総合研究域医学系 / Graduate School of Medical Sciences | |||||||||||||
| 書誌情報 |
Cerebral Cortex 巻 29, 号 8, p. 3540-3550, 発行日 2019-08-24 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 1047-3211 | |||||||||||||
| NCID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA10777916 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1093/cercor/bhy227 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Oxford University Press | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | PMID: 30247542 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Visuospatial working memory (WM), which is impaired in schizophrenia, depends on a distributed network including visual, posterior parietal, and dorsolateral prefrontal cortical regions. Within each region, information processing is differentially regulated by subsets of γ-aminobutyric acid (GABA) neurons that express parvalbumin (PV), somatostatin (SST), or vasoactive intestinal peptide (VIP). In schizophrenia, WM impairments have been associated with alterations of PV and SST neurons in the dorsolateral prefrontal cortex. Here, we quantified transcripts selectively expressed in GABA neuron subsets across four cortical regions in the WM network from comparison and schizophrenia subjects. In comparison subjects, PV mRNA levels declined and SST mRNA levels increased from posterior to anterior regions, whereas VIP mRNA levels were comparable across regions except for the primary visual cortex (V1). In schizophrenia subjects, each transcript in PV and SST neurons exhibited similar alterations across all regions, whereas transcripts in VIP neurons were unaltered in any region except for V1. These findings suggest that the contribution of each GABA neuron subset to inhibitory regulation of local circuitry normally differs across cortical regions of the visuospatial WM network and that in schizophrenia alterations of PV and SST neurons are a shared feature across these regions, whereas VIP neurons are affected only in V1. | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | Embargo Period 12 months | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | copyright © Oxford University Press | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 関連URI | ||||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy227/5106159 | |||||||||||||
| 関連名称 | https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy227/5106159 | |||||||||||||
| 関連URI | ||||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://academic.oup.com/cercor/article/29/8/3540/5106159 | |||||||||||||
| 関連名称 | https://academic.oup.com/cercor/article/29/8/3540/5106159 | |||||||||||||
