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肝移植後拒絶反応における類洞血管外血小板凝集関与の解明と新規治療の開発
https://doi.org/10.24517/00055800
https://doi.org/10.24517/00055800960582a3-e4b0-4fc4-b94f-3c0546734b87
名前 / ファイル | ライセンス | アクション |
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HO-PR-NAKANUMA-S-kaken 2018-5p.pdf (490.8 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2019-10-17 | |||||
タイトル | ||||||
タイトル | 肝移植後拒絶反応における類洞血管外血小板凝集関与の解明と新規治療の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of the involvement of extravasated platelets aggregation in graft function after liver transplantation | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00055800 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Nakanuma, Shinichi
× Nakanuma, Shinichi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院肝胆膵・移植外科 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2015-04-01 - 2018-03-31, p. 5p., 発行日 2018-05-26 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 肝移植後早期に血小板減少の継続を認めた症例の治療成績は不良であるが、この病態の解明は不十分である。本研究では、肝移植後早期に肝生検にて得られた肝組織やラット虚血再灌流障害モデルを用いて同病態の解明に取り組んだ。血小板は主に類洞血管外血小板凝集Extravasated platelets aggregation(EPA)の形態として認められ、同程度が強い症例ほど、血小板数やグラフト機能の低下を認めた。虚血再灌流障害モデルでは、抗血小板作用及び血管平滑筋拡張を要するPDE3阻害剤を虚血処置前に脾臓注入にて経門脈的に投与したところ、肝組織・機能障害、血小板減少および小腸障害の軽減を認めた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | There is increasing evidence that continuous thrombocytopenia soon after liver transplant (LT) is associated with a less favorable prognosis. Few pathophysiological studies have assessed post-LT thrombocytopenia. We elucidated the pathogenesis of thrombocytopenia after LT using the allograft tissue obtained after transplant and rat hepatic ischemic reperfusion injury model. Platelets were found mainly as extravasated platelet aggregates in local microenvironments. Platelet count after surgery and graft function were lower in EPA positive group than these of negative group. Pre-treatment of phosphodiesterase-3 inhibitor, milrinone by intraportal administration using splenic injection reduced hepatic ischemia-reperfusion injury minimizing small intestinal injury and platelet depletion in rats. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:15K19844, 研究期間(年度):2015-04-01 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝移植後拒絶反応における類洞血管外血小板凝集関与の解明と新規治療の開発」課題番号15K19844 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19844/15K19844seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=00640921 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=00640921 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19844/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19844/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19844/15K19844seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19844/15K19844seika/ |