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胃癌腹膜播種の微小環境における上皮間葉転換の解明と治療標的の意義
https://doi.org/10.24517/00058981
https://doi.org/10.24517/0005898137a044b0-c771-4ec9-bc8f-9e2d1a74832b
名前 / ファイル | ライセンス | アクション |
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ME-PR-KINOSHITA-J-kaken 2014-4p.pdf (599.8 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-10-08 | |||||
タイトル | ||||||
タイトル | 胃癌腹膜播種の微小環境における上皮間葉転換の解明と治療標的の意義 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of the mechanism of Epithelial-Mesenchymal Transition in peritoneal environment of gastric cancer | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00058981 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kinoshita, Jun
× Kinoshita, Jun |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2014 Fiscal Year Final Research Report 巻 2012-04-01 – 2014-03-31, p. 4p., 発行日 2014-05-21 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 胃癌腹膜転移側の宿主細胞である腹膜中皮細胞(HPMC)において、TGF-β1や胃癌細胞との共培養によるEMT(上皮間葉転換)誘導を証明した。またマウス皮下腫瘍モデルを用い、胃癌細胞とHPMCの共投与は腫瘍増殖能や間質線維化の増生に促進的に作用する事を示した。さらにBRM製剤であるPSKは非免疫学的機序である抗TGFβ作用によって、これらのEMT誘導に伴う癌間質の線維化を抑制する事を証明した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we evaluated the mechanism of EMT of Human PeritonealMesothelial Cell(HPMC) in in peritoneal environment of gastric cancer. We also investigated the inhibitory effect of PSK on the TGF/Smad signalling pathway and TGFb induced EMT in human HPMCs and gastric cancer cells. In vitro, TGFb increased the expression of E cadherin and decreased the expression of mesenchymal markers in HPMCs and which was suppressed by PSK. PSK suppressed TGFb induced phosphorylation of Smad2 in HPMCs in western blot analysis.In mouse subctaneous xenograft models, PSK inhibited the tumor fibrosis induced by co-inoculation of gastric cancer cells and HPMCs. PSK might have the potential to reduce TGFb induced activation of HPMCs in the peritoneal microenvironment of gastric cancer. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24791402, 研究期間(年度):2012-04-01 – 2014-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「胃癌腹膜播種の微小環境における上皮間葉転換の解明と治療標的の意義」課題番号24791402 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791402/24791402seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/search/?kw=90584855 | |||||
関連名称 | https://kaken.nii.ac.jp/ja/search/?kw=90584855 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791402/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791402/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791402/24791402seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791402/24791402seika/ |