| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-03-26 |
| タイトル |
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タイトル |
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00061537 |
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ID登録タイプ |
JaLC |
| 著者 |
Popivanova, Boryana K.
Kitamura, Kazuya
Wu, Yu
Kondo, Toshikazu
Kagaya, Takashi
Kaneko, Shuichi
Oshima, Masanobu
Fujii, Chifurni
Mukaida, Naofumi
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| 著者別表示 |
北村, 和哉
近藤, 稔和
加賀谷, 尚史
金子, 周一
大島, 正伸
向田, 直史
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学がん進展制御研究所 |
| 書誌情報 |
Journal of Clinical Investigation
巻 118,
号 2,
p. 560-570,
発行日 2008-02-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021-9738 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00695520 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1172/JCI32453 |
| 出版者 |
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出版者 |
American Society for Clinical Investigation |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To understand the mechanisms by which UC patients develop colon carcinomas, we used a mouse model of the disease whereby administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS) ingestion causes severe colonic inflammation and the subsequent development of multiple tumors. We found that treating WT mice with AOM and DSS increased TNF-α expression and the number of infiltrating leukocytes expressing its major receptor, p55 (TNF-Rp55), in the lamina propria and submucosal regions of the colon. This was followed by the development of multiple colonic tumors. Mice lacking TNF-Rp55 and treated with AOM and DSS showed reduced mucosal damage, reduced infiltration of macrophages and neutrophils, and attenuated subsequent tumor formation. WT mice transplanted with TNF-Rp55-deficient bone marrow also developed significantly fewer tumors after AOM and DSS treatment than either WT mice or TNF-Rp55-deficient mice transplanted with WT bone marrow. Furthermore, administration of etanercept, a specific antagonist of TNF-α, to WT mice after treatment with AOM and DSS markedly reduced the number and size of tumors and reduced colonic infiltration by neutrophils and macrophages. These observations identify TNF-α as a crucial mediator of the initiation and progression of colitis-associated colon carcinogenesis and suggest that targeting TNF-α may be useful in treating colon cancer in individuals with UC. |
| 権利 |
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権利情報 |
Copyright © Authors. American Society for Clinical Investigation |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jci.org/articles/view/32453/pdf |
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関連名称 |
https://www.jci.org/articles/view/32453/pdf |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jci.org/ |
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関連名称 |
https://www.jci.org/ |
CA-PR-MUKAIDA-N-560.pdf (1.6 MB)
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