| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-04-09 |
| タイトル |
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タイトル |
Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00061593 |
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ID登録タイプ |
JaLC |
| 著者 |
Mukai, Kanae
Komatsu, Emi
Nakajima, Yukari
Urai, Tamae
Nasruddin
Sugama, Junko
Nakatani, Toshio
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| 著者別表示 |
向井, 加奈恵
中島, 由加里
浦井, 珠恵
須釜, 淳子
中谷, 壽男
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域保健学系 |
| 書誌情報 |
PLoS ONE
巻 11,
号 14,
p. 0225880,
発行日 2019-11-27
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0225880 |
| 出版者 |
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出版者 |
Public Library of Science |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Topical estrogen application to wounds is effective in promoting cutaneous wound healing. However, whether it promotes cutaneous wound healing in delayed cutaneous wound healing associated with advanced age remains to be elucidated. This study aimed to evaluate the effect of topical estrogen application to wounds in cutaneous wound healing in 80-week-old female mice. C57BL/6J female mice aged 82–85 and 12 weeks old were submitted to two full-thickness wounds. Mice were divided into four groups: aged group, topical estrogen wound treatment aged group (aged-E), vehicle wound treatment aged group (aged-vehicle), and young group. Wound healing was observed until day 14. In the aged group, wound area ratio (wound area / initial wound area) was significantly higher on days 3–14, ratio of re-epithelialization was significantly lower on day 3 and tended to be lower on day 14, and neutrophil number was significantly higher on day 7 compared with the young group. In contrast, in the aged-E group, wound area ratio was significantly smaller on days 1–14, re-epithelialization ratio was significantly higher on days 3–14, and neutrophil and macrophage number was significantly lower on days 3 and 7 compared with the aged group. These results demonstrate that topical estrogen application to wounds in 80-week-old female mice promoted cutaneous wound healing by reducing wound area and inflammatory response and promoting re-epithelialization. |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225880 |
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関連名称 |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225880 |
ME-PR-NAKATANI-T-2019-0225880.pdf (474.2 kB)
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