| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-08-30 |
| タイトル |
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|
タイトル |
Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00061736 |
|
ID登録タイプ |
JaLC |
| 著者 |
Fujimura, Takashi
Ohta, Tetsuo
Oyama, Katsunobu
Miyashita, Tomoharu
Miwa, Koichi
|
| 著者別表示 |
藤村, 隆
太田, 哲生
尾山, 勝信
宮下, 知治
三輪, 晃一
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
World Journal of Gastroenterology
巻 12,
号 9,
p. 1336-1345,
発行日 2006
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1007-9327 |
| NCID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12048247 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3748/wjg.v12.i9.1336 |
| 出版者 |
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出版者 |
Baishideng Publishing Group Co |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory drugs (NSAIDs). However, coxibs also have an ability to inhibit tumor development of various kinds the same way that NSAIDs do. Many experimental studies using cell lines and animal models demonstrated an ability to prevent tumor proliferation of COX-2 inhibitors. After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP), which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S. Food and Drug Administration (FDA) immediately approved the clinical use of celecoxib for FAP patients. However, some coxibs were recently reported to increase the risk of serious cardiovascular events including heart attack and stroke. In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum, and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors. © 2006 The WJG Press. All rights reserved. |
| 権利 |
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|
権利情報 |
Copyright ©The Author(s). 2006 Published by Baishideng Publishing Group Inc. All rights reserved. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.wjgnet.com/ |
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|
関連名称 |
https://www.wjgnet.com/ |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.wjgnet.com/1007-9327/index.htm |
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|
関連名称 |
https://www.wjgnet.com/1007-9327/index.htm |
ME-PR-FUJIMURA-T-1336.pdf (810.8 kB)
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