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Clinical utility of next‐generation sequencing‐based panel testing under the universal health‐care system in japan: A retrospective analysis at a single university hospital
https://doi.org/10.24517/00062686
https://doi.org/10.24517/00062686afc70b1a-9359-4de8-800a-c38a5defccee
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-1121.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Clinical utility of next‐generation sequencing‐based panel testing under the universal health‐care system in japan: A retrospective analysis at a single university hospital | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062686 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Inagaki, Chiaki
× Inagaki, Chiaki× Maeda, Daichi× Hatake, Kazue× Sato, Yuki× Hashimoto, Kae× Sakai, Daisuke× Yachida, Shinichi× Nonomura, Norio× Satoh, Taroh |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Cancers 巻 13, 号 5, p. 1121-14p., 発行日 2021-03-05 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2072-6694 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.3390/cancers13051121 | |||||||
| 出版者 | ||||||||
| 出版者 | MDPI AG | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Next‐generation sequencing (NGS) assay is part of routine care in Japan owing to its reimbursement by Japan’s universal health‐care system; however, reimbursement is limited to patients who finished standard treatment. We retrospectively investigated 221 patients who underwent Foundation One CDX (F1CDx) at our hospital. Every F1CDx result was assessed at the molecular tumor board (MTB) for treatment recommendation. Based on patients’ preferences, presumed germline findings were also assessed at the MTB and disclosed at the clinic. In total, 204 patients underwent F1CDx and 195 patients completed the analysis; however, 13.8% of them could not re-ceive the report due to disease progression. Among 168 patients who received the results, 41.6% had at least one actionable alteration, and 3.6% received genomically matched treatment. Presumed germline findings were nominated in 24 patients, and 16.7% of them contacted a geneticist counse-lor. The NGS assay should be performed earlier in the clinical course to maximize the clinical ben-efit. Broader reimbursement for the NGS assay would enhance the delivery of precision oncology to patients. Access to clinical trials affects the number of patients who benefit from NGS. Addition-ally, the disclosure of presumed germline findings is feasible in clinical practice. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © MDPI AG | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.mdpi.com/journal/cancers | |||||||
| 関連名称 | http://www.mdpi.com/journal/cancers | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.mdpi.com/2072-6694/13/5/1121 | |||||||
| 関連名称 | https://www.mdpi.com/2072-6694/13/5/1121 | |||||||
