Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

前田, 大地; Shiraishi, Kouya; Okada, Yukinori; Takahashi, Atsushi; Kamatani, Yoichiro; Momozawa, Yukihide; Ashikawa, Kyota; Kunitoh, Hideo; Matsumoto, Shingo; Takano, Atsushi; Shimizu, Kimihiro; Goto, Akiteru; Tsuta, Koji; Watanabe, Shun-ichi; Ohe, Yuichiro; Watanabe, Yukio; Goto, Yasushi; Nokihara, Hiroshi; Furuta, Koh; Yoshida, Akihiko; Goto, Koichi; Hishida, Tomoyuki; Tsuboi, Masahiro; Tsuchihara, Katsuya; Miyagi, Yohei; Tanaka, Kazumi; Nakayama, Haruhiko; Yokose, Tomoyuki; Nagashima, Toshiteru; Ohtaki, Yoichi; Maeda, Daichi; Imai, Kazuhiro; Minamiya, Yoshihiro; Sakamoto, Hiromi; Saito, Akira; Shimada, Yoko; Sunami, Kuniko; Saito, Motonobu; Inazawa, Johji; Nakamura, Yusuke; Yoshida, Teruhiko; Yokota, Jun; Matsuda, Fumihiko; Matsuo, Keitaro; Daigo, Yataro; Kubo, Michiaki; Kohno, Takashi

doi:10.1038/ncomms12451

アイテムタイプ

学術雑誌論文 / Journal Article(1)

公開日

2021-06-28

タイトル

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

言語

eng

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

ID登録

10.24517/00062694

ID登録タイプ

JaLC

著者

Shiraishi, Kouya
Okada, Yukinori
Takahashi, Atsushi

Kamatani, Yoichiro

Momozawa, Yukihide

Ashikawa, Kyota
Kunitoh, Hideo
Matsumoto, Shingo
Takano, Atsushi
Shimizu, Kimihiro
Goto, Akiteru
Tsuta, Koji
Watanabe, Shun-ichi

Ohe, Yuichiro
Watanabe, Yukio
Goto, Yasushi
Nokihara, Hiroshi
Furuta, Koh
Yoshida, Akihiko
Goto, Koichi
Hishida, Tomoyuki
Tsuboi, Masahiro
Tsuchihara, Katsuya

Miyagi, Yohei
Tanaka, Kazumi
Nakayama, Haruhiko

Yokose, Tomoyuki
Nagashima, Toshiteru

Ohtaki, Yoichi
Maeda, Daichi

WEKO 97904
e-Rad 30585500

	Maeda, Daichi

Search repository

Imai, Kazuhiro
Minamiya, Yoshihiro

Sakamoto, Hiromi
Saito, Akira
Shimada, Yoko
Sunami, Kuniko
Saito, Motonobu
Inazawa, Johji
Nakamura, Yusuke
Yoshida, Teruhiko
Yokota, Jun
Matsuda, Fumihiko
Matsuo, Keitaro
Daigo, Yataro
Kubo, Michiaki
Kohno, Takashi

著者別表示

前田, 大地

提供者所属

内容記述タイプ

Other

内容記述

金沢大学医薬保健研究域医学系

書誌情報

Nature Research

巻 7, p. 12451, 発行日 2016-08-09

ISSN

収録物識別子タイプ

ISSN

収録物識別子

2041-1723

NCID

収録物識別子タイプ

NCID

収録物識別子

AA12645905

DOI

関連識別子

10.1038/ncomms12451

出版者

Nature Publishing Group

抄録

内容記述タイプ

Abstract

内容記述

Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10 '17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10 '9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.

権利

権利情報

著者版フラグ

出版タイプ

VoR

出版タイプResource

http://purl.org/coar/version/c_970fb48d4fbd8a85

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アイテム

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

× Shiraishi, Kouya

× Okada, Yukinori

× Takahashi, Atsushi

× Kamatani, Yoichiro

× Momozawa, Yukihide

× Ashikawa, Kyota

× Kunitoh, Hideo

× Matsumoto, Shingo

× Takano, Atsushi

× Shimizu, Kimihiro

× Goto, Akiteru

× Tsuta, Koji

× Watanabe, Shun-ichi

× Ohe, Yuichiro

× Watanabe, Yukio

× Goto, Yasushi

× Nokihara, Hiroshi

× Furuta, Koh

× Yoshida, Akihiko

× Goto, Koichi

× Hishida, Tomoyuki

× Tsuboi, Masahiro

× Tsuchihara, Katsuya

× Miyagi, Yohei

× Tanaka, Kazumi

× Nakayama, Haruhiko

× Yokose, Tomoyuki

× Nagashima, Toshiteru

× Ohtaki, Yoichi

× Maeda, Daichi

× Imai, Kazuhiro

× Minamiya, Yoshihiro

× Sakamoto, Hiromi

× Saito, Akira

× Shimada, Yoko

× Sunami, Kuniko

× Saito, Motonobu

× Inazawa, Johji

× Nakamura, Yusuke

× Yoshida, Teruhiko

× Yokota, Jun

× Matsuda, Fumihiko

× Matsuo, Keitaro

× Daigo, Yataro

× Kubo, Michiaki

× Kohno, Takashi

× 前田, 大地

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