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Expression of cell competition markers at the interface between p53 signature and normal epithelium in the human fallopian tube
https://doi.org/10.24517/00062698
https://doi.org/10.24517/000626989f1c8472-b8ee-4d8f-955e-d940aa96ce9b
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-e0156069.pdf (276.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Expression of cell competition markers at the interface between p53 signature and normal epithelium in the human fallopian tube | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062698 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Kito, Masahiko
× Kito, Masahiko× Maeda, Daichi× Kudo-Asabe, Yukitsugu× Sato, Naoki× Ie-Ming, Shih× Wang, Tian-Li× Tanaka, Masamitsu× Terada, Yukihiro× Goto, Akiteru |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
PLoS ONE 巻 11, 号 6, p. e0156069, 発行日 2016-06-03 |
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| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1932-6203 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1371/journal.pone.0156069 | |||||||
| 出版者 | ||||||||
| 出版者 | Public Library of Science | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | There is a growing body of evidence regarding cell competition between normal and mutant mammalian cells, which suggest that it may play a defensive role in the early phase of carcinogenesis. In vitro study in the past has shown that overexpression of vimentin in normal epithelial cells at the contact surface with transformed cells is essential for the cell competition involved in epithelial defense against cancer. In this study, we attempted to examine cell competition in human tissue in vivo by investigating surgically resected human fallopian tubes that contain p53 signatures and serous tubal intraepithelial lesions (STILs), a linear expansion of p53-immunopositive/TP53 mutant tubal epithelial cells that are considered as precursors of pelvic high grade serous carcinoma. Immunofluorescence double staining for p53 and the cell competition marker vimentin was performed in 21 sections of human fallopian tube tissue containing 17 p53 signatures and 4 STILs. The intensities of vimentin expression at the interface between p53-positive cells at the end of the p53 signature/STIL and adjacent p53-negative normal tubal epithelial cells were compared with the background tubal epithelium. As a result, the average vimentin intensity at the interfaces relative to the background intensity was 1.076 (95% CI, 0.9412-1.211 for p53 signature and 0.9790 (95% CI, 0.7206-1.237) for STIL. Thus, it can be concluded that overexpression of the cell competition marker vimentin are not observed in human tissue with TP53 alterations. © 2016 Kito et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Public Library of Science | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.plosone.org/ | |||||||
| 関連名称 | http://www.plosone.org/ | |||||||
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| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156069 | |||||||
| 関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156069 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160136 | |||||||
| 関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160136 | |||||||
