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Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis
https://doi.org/10.24517/00062705
https://doi.org/10.24517/00062705c860b2bb-2495-4e27-9c3e-3584f810a576
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-MAEDA-D-28652.pdf (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062705 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Akiyama, Yoshiyuki
× Akiyama, Yoshiyuki× Morikawa, Teppei× Maeda, Daichi× Shintani, Yukako× Niimi, Aya× Nomiya, Akira× Nakayama, Atsuhito× Igawa, Yasuhiko× Fukayama, Masashi× Homma, Yukio |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Scientific Reports 巻 6, p. 28652, 発行日 2016-06-24 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2045-2322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/srep28652 | |||||||
| 出版者 | ||||||||
| 出版者 | Nature Research | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | An up-regulated CXCR3 pathway and affluent plasma cell infiltration are characteristic features of Hunner type interstitial cystitis (HIC). We further examined these two features using bladder biopsy samples taken from 27 patients with HIC and 15 patients with non-IC cystitis as a control. The number of CD3-positive T lymphocytes, CD20-positive B lymphocytes, CD138-positive plasma cells, and CXCR3-positive cells was quantified by digital image analysis. Double-immunofluorescence for CXCR3 and CD138 was used to detect CXCR3 expression in plasma cells. Correlations between CXCR3 positivity and lymphocytic and plasma cell numbers and clinical parameters were explored. The density of CXCR3-positive cells showed no significant differences between HIC and non-IC cystitis specimens. However, distribution of CXCR3-positivity in plasma cells indicated co-localization of CXCR3 with CD138 in HIC specimens, but not in non-IC cystitis specimens. The number of CXCR3-positive cells correlated with plasma cells in HIC specimens alone. Infiltration of CXCR3-positive cells was unrelated to clinical parameters of patients with HIC. These results suggest that infiltration of CXCR3-positive plasma cells is a characteristic feature of HIC. The CXCR3 pathway and specific immune responses may be involved in accumulation/retention of plasma cells and pathophysiology of the HIC bladder. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Nature Research | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.nature.com/articles/srep28652 | |||||||
| 関連名称 | https://www.nature.com/articles/srep28652 | |||||||
