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Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report
https://doi.org/10.24517/00062707
https://doi.org/10.24517/000627072557a725-e2ca-4e04-b97b-3091fe24eb16
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-11-761.pdf (3.3 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062707 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Inagaki, Chiaki
× Inagaki, Chiaki× Maeda, Daichi× Kimura, Akie× Otsuru, Toru× Iwagami, Yoshifumi× Nishida, Naohiro× Sakai, Daisuke× Shitotsuki, Ryo× Yachida, Shinichi× Doki, Yuichiro× Satoh, Taroh |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
World Journal of Gastrointestinal Oncology 巻 11, 号 9, p. 761-767, 発行日 2019-09-15 |
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| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1948-5204 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.4251/wjgo.v11.i9.761 | |||||||
| 出版者 | ||||||||
| 出版者 | Baishideng Publishing Group Co | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | BACKGROUND Bile duct cancer constitutes gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICA), and extrahepatic cholangiocarcinoma (ECA). These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC, which sometimes becomes a point of discussion in clinical practice. Although these cancers demonstrate significant differences in their mutational landscape, several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary cancers. CASE SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2 (ERBB2) activating mutation on next-generation sequencing (NGS)-based genomic testing. One year later, a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological diagnosis. The histological findings of the hepatic lesion were similar to those of the primary lesion. Additionally, using NGS panel testing, the hepatic lesion was found to have ERBB2 activating mutation, which is the identical mutation detected in the sequencing result of the primary site. ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA. Therefore, in the present case, we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic recurrence. Additionally, this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical benefit. CONCLUSION This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC. © The Author(s) 2019. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Baishideng Publishing Group Co | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.wjgnet.com/1948-5204/index.htm | |||||||
| 関連名称 | http://www.wjgnet.com/1948-5204/index.htm | |||||||
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| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.wjgnet.com/1948-5204/full/v11/i9/761.htm | |||||||
| 関連名称 | https://www.wjgnet.com/1948-5204/full/v11/i9/761.htm | |||||||
