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Selenoprotein P controls oxidative stress in cornea
https://doi.org/10.24517/00062816
https://doi.org/10.24517/000628160b24ac8e-027f-4d16-b1af-502506e7f3e6
| 名前 / ファイル | ライセンス | アクション |
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FR-PR-HIGUCHI-A- e9911.pdf (325.0 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-07-05 | |||||||
| タイトル | ||||||||
| タイトル | Selenoprotein P controls oxidative stress in cornea | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062816 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Higuchi, Akihiro
× Higuchi, Akihiro× Takahashi, Kazuhiko× Hirashima, Masaki× Kawakita, Tetsuya× Tsubota, Kazuo |
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| 著者別表示 |
樋口, 明弘
× 樋口, 明弘
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学先端科学・社会共創推進機構 | |||||||
| 書誌情報 |
PLoS ONE 巻 5, 号 3, p. e9911, 発行日 2010-03-29 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1932-6203 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1371/journal.pone.0009911 | |||||||
| 出版者 | ||||||||
| 出版者 | Public Library of Science | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The ocular surface is always attacked by oxidative stress, and cornea epithelial cells are supposed to have their own recovery system against oxidative stress. Therefore we hypothesized that tears supply key molecules for preventing oxidative stress in cornea. The potential target key molecule we focused is selenoprotein P (SeP). SeP is a carrier of selenium, which is an essential trace element for many animals, for oxidative stress metabolism in the organism, and was extremely expressed in lacrimal gland. An experiment was performed with SeP eye drops in a rat dry eye model, prepared by removing the lacrimal glands. The anticipated improvement in corneal dry eye index and the suppression of oxidative stress markers were observed in SeP eye drop group. Furthermore, the concentration of SeP was significantly higher in dry eye patients compared with normal volunteers. Collectively, we concluded that tear SeP is a key molecule to protect the ocular surface cells against environmental oxidative stress. © 2010 Higuchi et al. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Public Library of Science | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.plosone.org/ | |||||||
| 関連名称 | http://www.plosone.org/ | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009911 | |||||||
| 関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009911 | |||||||
