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Changes in blood vessel maturation in the fibrous cap of the tumor rim
https://doi.org/10.24517/00062980
https://doi.org/10.24517/0006298020979207-fe58-4659-a79a-05cd12111a8f
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-NAITO-H-433.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2021-07-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Changes in blood vessel maturation in the fibrous cap of the tumor rim | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00062980 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Naito, Hisamichi
× Naito, Hisamichi× Takara, Kazuhiro× Wakabayashi, Taku× Kawahara, Hiroki× Kidoya, Hiroyasu× Takakura, Nobuyuki |
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| 著者別表示 |
内藤, 尚道
× 内藤, 尚道
× 高倉, 伸幸
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Cancer Science 巻 103, 号 3, p. 433-438, 発行日 2011-11-20 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1347-9032 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1349-7006 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11808050 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1111/j.1349-7006.2011.02157.x | |||||||||
| 出版者 | ||||||||||
| 出版者 | Japanese Cancer Association 日本癌学会 / wiley | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | It is widely accepted that blood vessels in the tumor microenvironment are immature because mural cell (MC) adhesion to endothelial cells (ECs) is broadly lacking. Hyperpermeability of the tumor vasculature then results in interstitial hypertension that mitigates against penetration of anticancer drugs into the depths of the tumor. It has been suggested that treatment with angiogenesis inhibitors normalizes blood vessels, resulting in restoration of normal permeability and improved drug delivery. However, recent reports suggest that cancer cell invasion is induced from the edge of the tumor into peripheral areas after treatment with angiogenesis inhibitors. Therefore, it is important to assess the status of blood vessels in the fibrous cap at the tumor rim after antiangiogenesis therapy. In the present study, we found that mature blood vessels in which ECs are covered with MCs are present in the fibrous cap. After treatment with angiogenesis inhibitors, immature blood vessels were destroyed and vascular function was significantly improved, but maturing blood vessels in which ECs were covered with MCs remained visible. These maturing blood vessels showed a less dilated character after treatment with the angiogenesis inhibitors. It is widely accepted that well-matured blood vessels are sheathed in extracellular matrix (ECM) and that cancer cells migrate along tracks made of ECM collagen fibers. Therefore, our data indicate the importance of destroying maturing blood vessels outside the tumor parenchyma to prevent cancer cell invasion. © 2011 Japanese Cancer Association. | |||||||||
| 権利 | ||||||||||
| 権利情報 | copyright © 日本癌学会 Japanese Cancer Association | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006/ | |||||||||
| 関連名称 | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006/ | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2011.02157.x | |||||||||
| 関連名称 | https://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2011.02157.x | |||||||||
