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Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells
https://doi.org/10.24517/00062991
https://doi.org/10.24517/00062991880ccc1c-606e-48ef-a04b-6262ac2545b0
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-NAITO-H-30941.pdf (5.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2021-07-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00062991 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Yamane, Keitaro
× Yamane, Keitaro× Naito, Hisamichi× Wakabayashi, Taku× Yoshida, Hironori× Muramatsu, Fumitaka× Iba, Tomohiro× Kidoya, Hiroyasu× Takakura, Nobuyuki |
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| 著者別表示 |
内藤, 尚道
× 内藤, 尚道
× 高倉, 伸幸
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Scientific Reports 巻 6, p. 30941, 発行日 2016-08-08 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2045-2322 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/srep30941 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nature Research / Nature Publishing Group | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | SLD5 is a member of the GINS complex, essential for DNA replication in eukaryotes. It has been reported that SLD5 is involved in early embryogenesis in the mouse, and cell cycle progression and genome integrity in Drosophila. SLD5 may be involved in malignant tumor progression, but its relevance in human cancer has not been determined. Here, we found strong SLD5 expression in both human bladder cancer tissues from patients and cell lines. Knockdown of SLD5 using small interfering RNA resulted in reduction of cell growth both in vitro and an in vivo xenograft model. Moreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. High level expression of DNA-methyltransferase (DNMT) 1 and IL-6 were also observed in bladder cancer cells. Knockdown of IL-6 led to downregulation of DNMT1 and SLD5 expression, suggesting that IL-6-induced overexpression of DNMT1 suppresses miR-370, resulting in high SLD5 expression. Our findings could contribute to understanding tumorigenic processes and progression of human bladder cancer, whereby inhibition of SLD5 could represent a novel strategy to prevent tumor growth. | |||||||||
| 権利 | ||||||||||
| 権利情報 | copyright © Nature Research | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.nature.com/articles/srep30941 | |||||||||
| 関連名称 | https://www.nature.com/articles/srep30941 | |||||||||
