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14C-標識アミノ酸, 糖類似物質および核酸前駆物質の腫瘍親和性
https://doi.org/10.24517/00065222
https://doi.org/10.24517/000652221cba330b-c232-4cc8-98a5-d4590655f595
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-SHIBA-K-33_526.pdf (3.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2022-02-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 14C-標識アミノ酸, 糖類似物質および核酸前駆物質の腫瘍親和性 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Comparative distribution study of 14C labeled amino acids, glucose-analogue and precursor of nucleic acid, as tumor seeking agents | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| ID登録 | ||||||||||||
| ID登録 | 10.24517/00065222 | |||||||||||
| ID登録タイプ | JaLC | |||||||||||
| 著者 |
柴, 和弘
× 柴, 和弘× 森, 厚文× 久田, 欣一 |
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| 著者別表示 |
Shiba, Kazuhiro
× Shiba, Kazuhiro
× Mori, Hirofumi
× Hisada, Kinichi
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| 提供者所属 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 金沢大学疾患モデル総合研究センター | |||||||||||
| 書誌情報 |
Radioisotopes 巻 33, 号 8, p. 526-532, 発行日 1984 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0033-8303 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 1884-4111 | |||||||||||
| NCID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00351589 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.3769/radioisotopes.33.8_526 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 日本アイソトープ協会 Japan Radioisotope Association | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | 14C-標識アミノ酸 (1-aminocyclopentane-1-carboxylic acid, α-amino isobutyric acid, L-leucine, DL-leucine) , 糖類似物質 (2-deoxy-2-fluoro-D-glucose) , 核酸前駆物質 (thymidine) をエールリッヒ担がんマウスおよび肝がんAH109A担がんラットに投与し, 臓器摘出法および全身オートラジオグラフィにて腫瘍親和性について比較検討した。その結果, 短半減期ポジトロン核種を用いたポジトロン放射型コンピュータ断層撮影 (ECT) 用には, 胸部領域を除いて糖類似物質, single photon ECT用には, 膵臓, 肝臓を除いて非天然アミノ酸が優れていることが示唆された。 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | As tumor-seeking agents, glucose analogues, natural amino acids, synthetic nonmetabolized amino acids, and precursor of nucleic acids, etc., labeled with positron emitter, such as 11C and 18F have been recently investigated. However, there are very few reports concerning comparative study of tumor uptake and tissue distribution of these agents. This preliminary paper describes comparative distribution and whole-body autoradiography of these agents. 14C labeled deoxy-2-fluoro-D-glucose (FDG), L-, DL-leucine, 1-aminocyclopentane carboxylic acid (ACPC) , α-amino isobutyric acid (α-AIB), and thymidine were intravenously injected through tail vein into separate groups of the experimental animals. As the experimental animals, the mice with Ehrlich tumor and the rats with Hepatoma AH109A were used. Within 30 min after injection, FDG had the highest tumor uptake and tumor to tissue ratios, although FDG was inferior to ACPC and thymidine in related to tumor to heart, lung and brain ratios. However, the time course study indicated that tumor uptake of ACPC, α-AIB and D-leucine increased with time, whereas those of other agents decreased with time or reached a plateau. Thus, at 120 min after injection, ACPC had the highest tumor uptake and tumor to tissue ratios, although ACPC was inferior to FDG in related to tumor to blood, liver and pancreas ratios. Autoradiogram of ACPC showed very clear tumor image as well as that of FDG. The above data suggest that synthetic nonmetabolized amino acids, such as ACPC may be promising as tumor-seeking agents, when used with a single photon emission computed tomography, while glucose analogue such as FDG, are the best tumor-seeking agent, when used with a positron emission computed tomography. |
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| 権利 | ||||||||||||
| 権利情報 | Copyright ©日本アイソトープ協会 Japan Radioisotope Association | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連URI | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/radioisotopes/-char/ja/ | |||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/browse/radioisotopes/-char/ja/ | |||||||||||
| 関連URI | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.jrias.or.jp/ | |||||||||||
| 関連名称 | http://www.jrias.or.jp/ | |||||||||||
