WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "e48f1df7-f7d4-4c0f-a6f3-02ee0d9c0295"}, "_deposit": {"created_by": 18, "id": "58974", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "58974"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00058974", "sets": ["1875"]}, "author_link": ["87", "78846", "85011", "43"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-06-13", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4535476", "bibliographicVolumeNumber": "2018", "bibliographic_titles": [{"bibliographic_title": "Contrast Media and Molecular Imaging"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小川, 数馬"}], "nameIdentifiers": [{"nameIdentifier": "87", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30347471"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30347471"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030347471"}]}, {"creatorNames": [{"creatorName": "柴, 和弘"}], "nameIdentifiers": [{"nameIdentifier": "43", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040143929"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The vesicular acetylcholine transporter (VAChT), a presynaptic cholinergic neuron marker, is a potential internal molecular target for the development of an imaging agent for early diagnosis of neurodegenerative disorders with cognitive decline such as Alzheimer\u0027s disease (AD). Since vesamicol has been reported to bind to VAChT with high affinity, many vesamicol analogs have been studied as VAChT imaging agents for the diagnosis of cholinergic neurodeficit disorder. However, because many vesamicol analogs, as well as vesamicol, bound to sigma receptors (σ1 and σ2) besides VAChT, almost all the vesamicol analogs have been shown to be unsuitable for clinical trials. In this report, the relationships between the chemical structure and the biological characteristics of these developed vesamicol analogs were investigated, especially the in vitro binding profile and the in vivo regional brain accumulation. © 2018 Kazuma Ogawa and Kazuhiro Shiba.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学疾患モデル総合研究センター", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00065236", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Hindawi Limited"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1155/2018/4535476", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.hindawi.com/journals/cmmi/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.hindawi.com/journals/cmmi/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2018 Kazuma Ogawa and Kazuhiro Shiba.is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12058342", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1555-4309", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ogawa, Kazuma"}], "nameIdentifiers": [{"nameIdentifier": "78846", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30347471", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30347471"}]}, {"creatorNames": [{"creatorName": "Shiba, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "85011", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40143929"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-01-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SHIBA-K-4535476.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "ME-PR-SHIBA-K-4535476.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/58974/files/ME-PR-SHIBA-K-4535476.pdf"}, "version_id": "a204175b-3c9e-45a7-bc61-507671558000"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In Vivo and in Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "In Vivo and in Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents"}]}, "item_type_id": "4", "owner": "18", "path": ["1875"], "permalink_uri": "https://doi.org/10.24517/00065236", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-01-28"}, "publish_date": "2022-01-28", "publish_status": "0", "recid": "58974", "relation": {}, "relation_version_is_last": true, "title": ["In Vivo and in Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents"], "weko_shared_id": -1}
In Vivo and in Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents
https://doi.org/10.24517/00065236
https://doi.org/10.24517/0006523619c3ef42-31f0-482b-98f6-6ace45012b44
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-SHIBA-K-4535476.pdf (1.8 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-01-28 | |||||
タイトル | ||||||
タイトル | In Vivo and in Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00065236 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Shiba, Kazuhiro |
|||||
著者別表示 |
小川, 数馬
× 小川, 数馬× 柴, 和弘 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学疾患モデル総合研究センター | |||||
書誌情報 |
Contrast Media and Molecular Imaging 巻 2018, p. 4535476, 発行日 2018-06-13 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1555-4309 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12058342 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2018/4535476 | |||||
出版者 | ||||||
出版者 | Hindawi Limited | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The vesicular acetylcholine transporter (VAChT), a presynaptic cholinergic neuron marker, is a potential internal molecular target for the development of an imaging agent for early diagnosis of neurodegenerative disorders with cognitive decline such as Alzheimer's disease (AD). Since vesamicol has been reported to bind to VAChT with high affinity, many vesamicol analogs have been studied as VAChT imaging agents for the diagnosis of cholinergic neurodeficit disorder. However, because many vesamicol analogs, as well as vesamicol, bound to sigma receptors (σ1 and σ2) besides VAChT, almost all the vesamicol analogs have been shown to be unsuitable for clinical trials. In this report, the relationships between the chemical structure and the biological characteristics of these developed vesamicol analogs were investigated, especially the in vitro binding profile and the in vivo regional brain accumulation. © 2018 Kazuma Ogawa and Kazuhiro Shiba. | |||||
権利 | ||||||
権利情報 | Copyright © 2018 Kazuma Ogawa and Kazuhiro Shiba.is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.hindawi.com/journals/cmmi/ | |||||
関連名称 | https://www.hindawi.com/journals/cmmi/ |