| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-01-27 |
| タイトル |
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タイトル |
Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00065243 |
|
ID登録タイプ |
JaLC |
| 著者 |
Ogawa, Kazuma
Higashi, Takuma
Mishiro, Kenji
Wakabayashi, Hiroshi
Shiba, Kazuhiro
Odani, Akira
Kinuya, Seigo
|
| 著者別表示 |
小川, 数馬
三代, 憲司
若林, 大志
柴, 和弘
小谷, 明
絹谷, 清剛
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学疾患モデル総合研究センター |
| 書誌情報 |
Scientific Reports
巻 10,
号 1,
p. 11917,
発行日 2020-07-17
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-020-68846-x |
| 出版者 |
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出版者 |
Nature Research |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
[223Ra]RaCl2 is the first alpha-particle emitting radiopharmaceutical to be used for castration-resistant prostate cancer patients with bone metastases because of its excellent therapeutic effects. [223Ra]RaCl2 is excreted via the intestine into feces, and some is absorbed from the intestine into the blood, which may be undesirable in terms of the exposure to radiation. Recently, we showed that a complex of myo-inositol-hexakisphosphate (InsP6) with zinc is a useful decorporation agent against radiostrontium. In this study, we hypothesized that Zn-InsP6 could bind to not only strontium but also to radium, and could inhibit the absorption of radium from the intestine. In in vitro binding experiments, Zn-InsP6 showed a high binding affinity for radium. In in vivo biodistribution experiments by intravenous injection of [223Ra]RaCl2 after treatment of Zn-InsP6, mice treated with Zn-InsP6 showed significantly lower bone accumulation of radioactivity (34.82 ± 1.83%Dose/g) than the mice in the non-treatment control group (40.30 ± 2.78%Dose/g) at 48 h postinjection. These results indicate that Zn-InsP6 bound radium in the intestine and inhibited the absorption of radium into the blood. Therefore, the insoluble Zn-InsP6 complex has high potential to decrease the side effects of [223Ra]RaCl2. © 2020, The Author(s). |
| 権利 |
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権利情報 |
Copyright © The Author(s) 2020. |
| 権利 |
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権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.nature.com/srep/index.html |
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関連名称 |
http://www.nature.com/srep/index.html |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41598-020-68846-x |
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関連名称 |
https://www.nature.com/articles/s41598-020-68846-x |
ME-PR-SHIBA-K-10.11917.pdf (1.0 MB)
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