| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-01-27 |
| タイトル |
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タイトル |
Serial examination of cardiac function and perfusion in growing rats using SPECT/CT for small animals |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00065244 |
|
ID登録タイプ |
JaLC |
| 著者 |
Hiromasa, Tomo
Taki, Junichi
Wakabayashi, Hiroshi
Inaki, Anri
Okuda, Koichi
Shibutani, Takayuki
Shiba, Kazuhiro
Kinuya, Seigo
|
| 著者別表示 |
廣正, 智
瀧, 淳一
若林, 大志
稲木, 杏吏
澁谷, 孝行
柴, 和弘
絹谷, 清剛
|
| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学疾患モデル総合研究センター |
| 書誌情報 |
Scientific Reports
巻 10,
号 1,
p. 160,
発行日 2020-01-13
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-019-57032-3 |
| 出版者 |
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出版者 |
Nature Research |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Few studies have evaluated myocardial perfusion and ventricular function in normal, growing rats. We, therefore, evaluated serial changes in cardiac perfusion and function during the growth of normal rats using single photon emission computed tomography (SPECT) with technetium (99mTc)-sestamibi. Gated SPECT was serially performed in six normal rats. The left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were calculated with Quantitative Gated SPECT software. The perfusion distribution was calculated as the percentage uptake of each of the 17 segments using Quantitative Perfusion SPECT software. As expected, the body weight (BW) of the rats increased with growth, but their heart rates (HR) did not change over time. EF decreased very slowly over time and showed a negative correlation with BW. EDV, ESV and SV showed strong positive correlations with BW. There were no significant differences in the percentage segmental uptake in 13 of the 17 segments during growth, except for three basal and one apical segments. Therefore, a single normal database could be applied for the evaluation of perfusion abnormalities in rats of at least 8 to 28 weeks old. © 2020, The Author(s). |
| 権利 |
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権利情報 |
Copyright © The Author(s) 2020. |
| 権利 |
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権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.nature.com/srep/index.html |
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関連名称 |
http://www.nature.com/srep/index.html |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41598-019-57032-3 |
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関連名称 |
https://www.nature.com/articles/s41598-019-57032-3 |
ME-PR-SHIBA-K-10.160.pdf (1.4 MB)
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