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  1. J-2. 疾患モデル総合研究センター
  2. j-2 10. 学術雑誌掲載論文
  3. 1. 査読済論文

Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis

https://doi.org/10.24517/00065246
https://doi.org/10.24517/00065246
bbb48b19-86ca-4135-896d-a58c2791204a
名前 / ファイル ライセンス アクション
ME-PR-SHIBA-K-e001367.pdf ME-PR-SHIBA-K-e001367.pdf (6.1 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-01-27
タイトル
タイトル Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00065246
ID登録タイプ JaLC
著者 Ho, Tuyen Thuy Bich

× Ho, Tuyen Thuy Bich

WEKO 103875

Ho, Tuyen Thuy Bich

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Nasti, Alessandro

× Nasti, Alessandro

WEKO 103876

Nasti, Alessandro

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Seki, Akihiro

× Seki, Akihiro

WEKO 74045
e-Rad 00733859

Seki, Akihiro

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Komura, Takuya

× Komura, Takuya

WEKO 85396
e-Rad 90623322

Komura, Takuya

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Inui, Hiiro

× Inui, Hiiro

WEKO 103879

Inui, Hiiro

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Kozaka, Takashi

× Kozaka, Takashi

WEKO 80506
e-Rad 50579836

Kozaka, Takashi

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Kitamura, Yoji

× Kitamura, Yoji

WEKO 80169
e-Rad 10368483

Kitamura, Yoji

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Shiba, Kazuhiro

× Shiba, Kazuhiro

WEKO 85011
e-Rad 40143929

Shiba, Kazuhiro

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Yamashita, Taro

× Yamashita, Taro

WEKO 21405
金沢大学研究者情報 90377432
研究者番号 90377432

Yamashita, Taro

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Yamashita, Tatsuya

× Yamashita, Tatsuya

WEKO 74241
e-Rad 30334783

Yamashita, Tatsuya

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Mizukoshi, Eishiro

× Mizukoshi, Eishiro

WEKO 74242
e-Rad 90345611

Mizukoshi, Eishiro

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Kawaguchi, Kazunori

× Kawaguchi, Kazunori

WEKO 88871
e-Rad 90579632

Kawaguchi, Kazunori

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Wada, Takashi

× Wada, Takashi

WEKO 70236
e-Rad 40334784

Wada, Takashi

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Honda, Masao

× Honda, Masao

WEKO 74055
e-Rad 00272980

Honda, Masao

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Kaneko, Shuichi

× Kaneko, Shuichi

WEKO 77802
e-Rad 60185923

Kaneko, Shuichi

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Sakai, Yoshio

× Sakai, Yoshio

WEKO 70371
e-Rad 80401925

Sakai, Yoshio

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著者別表示 関, 晃裕

× 関, 晃裕

関, 晃裕

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小村, 卓也

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小村, 卓也

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小阪, 孝史

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小阪, 孝史

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北村, 暘二

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北村, 暘二

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柴, 和弘

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柴, 和弘

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山下, 太郎

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山下, 太郎

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水腰, 英四郎

× 水腰, 英四郎

水腰, 英四郎

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川口, 和紀

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川口, 和紀

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和田, 隆志

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和田, 隆志

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本多, 政夫

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本多, 政夫

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金子, 周一

× 金子, 周一

金子, 周一

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酒井, 佳夫

× 酒井, 佳夫

酒井, 佳夫

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提供者所属
内容記述タイプ Other
内容記述 金沢大学疾患モデル総合研究センター
書誌情報 Journal for ImmunoTherapy of Cancer

巻 8, 号 2, p. e001367, 発行日 2020
ISSN
収録物識別子タイプ ISSN
収録物識別子 2051-1426
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1136/jitc-2020-001367
出版者
出版者 BMJ Publishing Group
抄録
内容記述タイプ Abstract
内容記述 Background Pancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to the lack of efficacious chemotherapy. Immune checkpoint inhibitors, including anti-programmed cell death 1 (anti-PD-1) antibodies, are novel promising forms of systemic immunotherapy. In the current study, we assessed whether gemcitabine (GEM) combined with anti-PD-1 antibody treatment was efficacious as immunochemotherapy for advanced PDAC using a murine model of liver metastasis. Methods The murine model of PDAC liver metastasis was established by intrasplenically injecting the murine pancreatic cancer cell line PAN02 into immunocompetent C57BL/6J mice. The mice were treated with an anti-PD-1 antibody, GEM, or a combination of GEM plus anti-PD-1 antibody, and compared with no treatment (control); liver metastases, immune cell infiltration, gene expression, immune cell response phenotypes, and overall survival were investigated. Results In the metastatic tumor tissues of mice treated with GEM plus anti-PD-1 antibody, we observed the increased infiltration of Th1 lymphocytes and M1 macrophages. Gene expression profile analysis of peripheral blood cells obtained from mice treated with GEM plus anti-PD-1 antibody clearly highlighted T cell and innate immune signaling pathways. Survival of PDAC liver metastasis mice was significantly prolonged by the combination therapy (median survival, 66 days) when compared with that of GEM alone treatment (median survival, 56 days). Expanded lymphocytes, which were isolated from the splenocytes of PDAC liver metastasis mice treated with GEM plus anti-PD-1 antibody, had an increased number of M1 macrophages. Conclusion The combination of anti-PD-1 antibody immunotherapy with GEM was beneficial to treat a murine model of PDAC liver metastasis by enhancing the immune response mediated by Th1 lymphocytes and M1 macrophages and was associated with CD8+ T cells. ©
権利
権利情報 Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連URI
識別子タイプ URI
関連識別子 https://jitc.bmj.com/
関連名称 https://jitc.bmj.com/
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