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Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion
https://doi.org/10.24517/00065248
https://doi.org/10.24517/00065248b36d6b59-10f4-4551-94cd-3dd9b9bf7688
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-2015-5-21.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2022-01-31 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00065248 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Taki, Junichi
× Taki, Junichi× Inaki, Anri× Wakabayashi, Hiroshi× Matsunari, Ichiro× Imanaka-Yoshida, Kyoko× Ogawa, Kazuma× Hiroe, Michiaki× Shiba, Kazuhiro× Yoshida, Toshimichi |
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| 著者別表示 |
瀧, 淳一
× 瀧, 淳一
× 稲木, 杏吏
× 若林, 大志
× 小川, 数馬
× 柴, 和弘
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| 提供者所属 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 金沢大学疾患モデル総合研究センター | |||||||||||||||
| 書誌情報 |
EJNMMI Research 巻 5, 号 1, p. 21, 発行日 2015-04-02 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 2191-219X | |||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1186/s13550-015-0100-8 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Springer Verlag | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Background Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using 125I-labeled anti-TNC antibody (125I-TNC-Ab) in a rat model of ischemia and reperfusion. Methods In control rats (n = 27), the left coronary artery (LCA) was occluded for 30 min followed by reperfusion for 1, 3, 7, and 14 days. PC (n = 27) was performed just after the reperfusion. At the time of the study, 125I-TNC-Ab (1.0 to 2.5 MBq) was injected. Six to 9 h later, to verify the area at risk, 99mTc-MIBI (100 to 200 MBq) was injected intravenously just after the LCA reocclusion, with the rats sacrificed 1 min later. Dual tracer autoradiography was performed to assess 125I-TNC-Ab uptake and area at risk. To examine the ventricular remodeling, echocardiography was performed 2 M after reperfusion in both groups. Results In control rats, 125I-TNC-Ab uptake ratio at 1 day after reperfusion was 3.73 ± 0.71 and increased at 3 days (4.65 ± 0.87), followed by a significant reduction at 7 days (2.91 ± 0.55, P < 0.005 vs 3 days) and14 days (2.01 ± 0.17, P < 0.005 vs 1 and 3 days). PC attenuated the 125I-TNC-Ab uptake throughout the reperfusion time from 1 to 14 days; 2.59 ± 0.59 at 1 day, P < 0.05: 3.10 ± 0.42 at 3 days, P < 0.005: 1.93 ± 0.37 at 7 days, P < 0.05: 1.40 ± 0.07 at 14 days, P < 0.001. In echocardiography, PC reduced the ventricular end-diastolic and systolic dimensions (1.00 ± 0.06 cm to 0.83 ± 0.14 cm (P < 0.05) and 0.90 ± 0.15 cm to 0.62 ± 0.19 cm (P < 0.05), respectively) and prevented a decline of ventricular percentage fractional shortening (10.5 ± 3.7 to 28.2 ± 10.7, P < 0.005). Conclusions These data indicate that 125I-TNC-Ab imaging may be a way to monitor myocardial injury, the subsequent repair process, and its response to novel therapeutic interventions like PC by visualizing TNC expression. |
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| 権利 | ||||||||||||||||
| 権利情報 | Copyright © 2015 Taki et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | http://www.ejnmmires.com/ | |||||||||||||||
| 関連名称 | http://www.ejnmmires.com/ | |||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | https://ejnmmires.springeropen.com/articles/10.1186/s13550-015-0100-8 | |||||||||||||||
| 関連名称 | https://ejnmmires.springeropen.com/articles/10.1186/s13550-015-0100-8 | |||||||||||||||
