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Molecular recognition of paired receptors in the immune system
https://doi.org/10.24517/00067077
https://doi.org/10.24517/00067077087c92e6-f02f-4189-a5d6-dcce0124846a
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-FURUKAWA-A-3-429.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2022-09-12 | |||||||
| タイトル | ||||||||
| タイトル | Molecular recognition of paired receptors in the immune system | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00067077 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Kuroki, Kimiko
× Kuroki, Kimiko× Furukawa, Atsushi× Maenaka, Katsumi |
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| 著者別表示 |
古川, 敦
× 古川, 敦
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
Frontiers in Microbiology 巻 3, p. 429, 発行日 2012-12-31 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1664-302X | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.3389/fmicb.2012.00429 | |||||||
| 出版者 | ||||||||
| 出版者 | Frontiers Research Foundation | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Cell surface receptors are responsible for regulating cellular function on the front line, the cell membrane. Interestingly, accumulating evidence clearly reveals that the members of cell surface receptor families have very similar extracellular ligand-binding regions but opposite signaling systems, either inhibitory or stimulatory. These receptors are designated as paired receptors. Paired receptors often recognize not only physiological ligands but also non-self ligands, such as viral and bacterial products, to fight infections. In this review, we introduce several representative examples of paired receptors, focusing on two major structural superfamilies, the immunoglobulin-like and the C-type lectin-like receptors, and explain how these receptors distinguish self and non-self ligands to maintain homeostasis in the immune system.We further discuss the evolutionary aspects of these receptors as well as the potential drug targets for regulating diseases. © 2012 Kuroki, Furukawa and Maenaka. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright: © 2012 Kuroki, Furukawa and Maenaka. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full | |||||||
| 関連名称 | https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.frontiersin.org/journals/microbiology | |||||||
| 関連名称 | https://www.frontiersin.org/journals/microbiology | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.frontiersin.org/ | |||||||
| 関連名称 | http://www.frontiersin.org/ | |||||||
