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Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan entamoeba histolytica
https://doi.org/10.24517/00067078
https://doi.org/10.24517/00067078b6c9a968-937b-468e-8257-abc4f7690168
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-FURUKAWA-A-81-1829.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2022-09-12 | |||||||
| タイトル | ||||||||
| タイトル | Cysteine protease-binding protein family 6 mediates the trafficking of amylases to phagosomes in the enteric protozoan entamoeba histolytica | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00067078 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Furukawa, Atsushi
× Furukawa, Atsushi× Nakada-Tsukui, Kumiko× Nozaki, Tomoyoshi |
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| 著者別表示 |
古川, 敦
× 古川, 敦
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
Infection and Immunity 巻 81, 号 5, p. 1820-1829, 発行日 2013-03 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0019-9567 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1098-5522 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00673732 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1128/IAI.00915-12 | |||||||
| 出版者 | ||||||||
| 出版者 | American Society for Microbiology | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Phagocytosis plays a pivotal role in nutrient acquisition and evasion from the host defense systems in Entamoeba histolytica, the intestinal protozoan parasite that causes amoebiasis. We previously reported that E. histolytica possesses a unique class of a hydrolase receptor family, designated the cysteine protease-binding protein family (CPBF), that is involved in trafficking of hydrolases to lysosomes and phagosomes, and we have also reported that CPBF1 and CPBF8 bind to cysteine proteases or α-hexosaminidase β-subunit and lysozymes, respectively. In this study, we showed by immunoprecipitation that CPBF6, one of the most highly expressed CPBF proteins, specifically binds to β-amylase and γ-amylase. We also found that CPBF6 is localized in lysosomes, based on immunofluorescence imaging. Immunoblot and proteome analyses of the isolated phagosomes showed that CPBF6 mediates transport of amylases to phagosomes. We also demonstrated that the carboxyl-terminal cytosolic region of CPBF6 is engaged in the regulation of the trafficking of CPBF6 to phagosomes. Our proteome analysis of phagosomes also revealed new potential phagosomal proteins. © 2013, American Society for Microbiology. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © 2013 American Society for Microbiology | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.asm.org/doi/epdf/10.1128/IAI.00915-12?src=getftr | |||||||
| 関連名称 | https://journals.asm.org/doi/epdf/10.1128/IAI.00915-12?src=getftr | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.asm.org/journal/iai | |||||||
| 関連名称 | https://journals.asm.org/journal/iai | |||||||
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| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.asm.org/ | |||||||
| 関連名称 | http://www.asm.org/ | |||||||
