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Mblk-1 transcription factor family: Its roles in various animals and regulation by NOL4 splice variants in Mammals
http://hdl.handle.net/2297/47085
http://hdl.handle.net/2297/47085ee6e9ea8-1e79-4e14-b68a-b6b9d4e0cf1a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TE-PR-KIYA-S-246.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Mblk-1 transcription factor family: Its roles in various animals and regulation by NOL4 splice variants in Mammals | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takayanagi-Kiya, Seika
× Takayanagi-Kiya, Seika× Kiya, Taketoshi× Kunieda, Takekazu× Kubo, Takeo |
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| 書誌情報 |
International Journal of Molecular Sciences 巻 18, 号 2, p. 246, 発行日 2017-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1661-6596 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/ijms18020246 | |||||
| 出版者 | ||||||
| 出版者 | MDPI AG | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Transcription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and then provides an overview of the studies of Mblk-1 and their homologs. Mblk-1 family proteins are found broadly in animals and are shown to affect transcription activities. Studies have revealed that the mammalian homologs can interact with several cofactors and together regulate transcription. Interestingly, a recent study using the mouse homologs, Mlr1 and Mlr2, showed that one of their cofactor proteins, NOL4, have several splice variants with different effects on the transactivation activities of Mlr proteins. These findings suggest that there is an additional layer of the regulation of Mblk-1 family proteins by cofactor splice variants and provide novel insights into our current understanding of the roles of the conserved transcription factor family. © 2017 by the authors; licensee MDPI, Basel, Switzerland. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
