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Effect of Extremely Low-Frequency(ELF) Magnetic Field on Anticancer Drugs Potency
http://hdl.handle.net/2297/48312
http://hdl.handle.net/2297/48312f052d32e-94ae-4561-b72d-e56deba95467
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TE-PR-YAMADA-S-322.pdf (256.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Effect of Extremely Low-Frequency(ELF) Magnetic Field on Anticancer Drugs Potency | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kakikawa, Makiko
× Kakikawa, Makiko× Yamada, Sotoshi |
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| 書誌情報 |
IEEE Transactions on Maggetics 巻 48, 号 11, p. 2869-2872, 発行日 2012-11-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0018-9464 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00667933 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1109/TMAG.2012.2200881 | |||||
| 出版者 | ||||||
| 出版者 | Institute of Electrical and Electronics Engineers IEEE | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There are some reports about combined effects of electromagnetic fields with known carcinogens, toxic physical or chemical agents. In previous study, we observed that magnetic fields (60 Hz, 50 mT) enhance cytotoxicity of mitomycin C on E.coli bacterium. However, it has not been clear about the effective condition of magnetic fields (magnetic flux density, frequency, exposure time etc.) on the potency of chemical agents. In this study, we investigated the effective density and the action mechanisms of magnetic fields on the enhancement of drugs potency. The result suggested that the enhancing effect of mitomycin C potency by exposure to magnetic fields depended on the magnetic flux density. The potency of cisplatin, widely used in clinical cancer chemotherapy, was also enhanced by exposure to 60 Hz, 50 mT magnetic fields. The analysis of the potency of supernatant remaining drugs in the culture medium indicated that the intracellular drug potency was increased and extracellular drug potency was decreased by exposure to magnetic fields. The values of drug potency revealed a significant inverse correlation between intracellular and extracellular cells. These results suggested that magnetic fields (60 Hz, 50 mT) change the permeability of cell membrane and influence the drug intake. | |||||
| 権利 | ||||||
| 権利情報 | © 1965-2012 IEEE. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
